alexa A Randomized, Double-Blind, Placebo-Controlled Study of
ISSN: 2167-0846

Journal of Pain & Relief
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Research Article

A Randomized, Double-Blind, Placebo-Controlled Study of the Analgesic Efficacy of Intravenous Acetaminophen in Ambulatory Surgery

Alex Konstantatos1,2*, Julian Smith1 and Margaret Angliss1
1Department of Anaesthesia and Perioperative Medicine, Alfred Hospital, Melbourne, Australia
2Senior Lecturer, Department of Medicine, Monash University, Australia
Corresponding Author : Alex Konstantatos
Department of Anaesthesia and Perioperative Medicine
Alfred Hospital, Monash University
Melbourne, Australia
Fax: 0390762813
E-mail: [email protected]
Received January 10, 2012; Accepted February 09, 2012; Published February 15, 2012
Citation: Konstantatos A, Smith J, Angliss M (2012) A Randomized, Double-Blind, Placebo-Controlled Study of the Analgesic Efficacy of Intravenous Acetaminophen in Ambulatory Surgery. J Pain Relief 1:104. doi: 10.4172/2167-0846.1000104
Copyright: © 2012 Konstantatos A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Purpose: We investigated whether intraoperative intravenous acetaminophen has the potential to reduce pain after ambulatory surgery and reduce time to discharge from the post anaesthesia care unit and hospital. Methods: We tested this hypothesis by conducting a prospective randomized, double-blind clinical trial in patients undergoing ambulatory surgery. A total of 145 patients were randomized to pre and postoperative placebo (50), intravenous (IV) operative and postoperative oral acetaminophen (49), and pre and postoperative oral acetaminophen (48). Results: The primary end point; visual analogue scale mean pain intensity over 24 hours after completion of surgery, was not significantly different between the 3 groups, control group 2.0 (1.6), mean (SD), (IV) acetaminophen group 2.1 (1.9) and oral acetaminophen group 2.1 (1.6); (p=0.93). Time to fitness for discharge from the postoperative care unit (p=0.77) and time to fitness for discharge from hospital (p=0.27) also did not vary significantly between the three groups. Conclusion: The addition of intraoperative IV acetaminophen to a standard analgesia regimen in patients undergoing ambulatory surgery did not significantly improve pain control or discharge times after surgery compared with pre and postoperative oral acetaminophen or placebo.

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