alexa Burden of Chronic Low Back Pain with a Neuropathic Pain
ISSN: 2167-0846

Journal of Pain & Relief
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Burden of Chronic Low Back Pain with a Neuropathic Pain Component: Retrospective Chart Review and Cross-sectional Survey among Adults Seeking Treatment in the United States

Alesia Sadosky1*, Caroline Schaefer2, Rachael Mann3, Bruce Parsons4, Rebecca Baik5, Srinivas Nalamachu6, Brett R Stacey7, Michael Tuchman8, Alan Anschel9 and Edward Nieshoff10
1Pfizer, Inc. 235 East 42nd Street New York, NY 10017, USA
2Covance Market Access Services Inc. 9801 Washingtonian Blvd 9th Floor, Gaithersburg, MY, USA
3Covance Market Access Services Inc. 10300 Campus Point Drive, Suite 225, San Diego, USA
4Pfizer, Inc. 235 East 42nd Street, New York, USA
5Covance Market Access Services Inc. 9801 Washingtonian Blvd 9th Floors, Gaithersburg, MY, USA
6International Clinical Research Institute 8675 College Blvd, Suite 150, Overland Park, USA
7Oregon Health & Science University Mail Code CH4P, 3303 SW Bond Ave, Portland, USA
8Palm Beach Neurological Centers 3365 Burns Road, Suite 203, Palm Beach Gardens, USA
9Rehabilitation Institute of Chicago, 345 E. Superior St., Chicago, USA
10Rehabilitation Institutes of Michigan/Wayne State University, USA
Corresponding Author : Alesia Sadosky
Pfizer Inc. 235 East 42nd Street New York, NY 10017 USA
Tel: 212-733-9491
Fax: 212-309-5294
E-mail: [email protected]
Received August 13, 2014; Accepted October 31, 2014; Published November 02, 2014
Citation: Sadosky A, Schaefer C, Mann R, Parsons B, Baik R, et al. (2014) Burden of Chronic Low Back Pain with a Neuropathic Pain Component: Retrospective Chart Review and Cross-sectional Survey among Adults Seeking Treatment in the United States. J Pain Relief 3:163. doi: 10.4172/2167-0846.1000163
Copyright: © 2014 Sadosky A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Chronic low back pain (CLBP) is highly prevalent, and between 35% and 55% of individuals with CLBP suffer from a neuropathic pain component (CLBP-NeP). Limited data on the economic and patient burden in this CLBP subgroup have been published.


This observational study aimed to characterize burden among CLBP-NeP subjects (n=106) recruited during routine physician visits in the United States. Subjects completed a questionnaire to capture pain severity, function, health status, sleep, anxiety/depression, lost productivity, demographics, employment status, and out-of- pocket expenses. Investigators completed a 6-month retrospective chart review to capture clinical characteristics and CLBP-NeP-related healthcare resource use. Based on average pain severity scores, subjects were stratified into mild, moderate, and severe pain groups. Summary statistics were calculated, and differences across severity groups were evaluated.


Subjects’ mean (SD) age was 54.1 (11.9) years; 57.5% were female. Most subjects had at least one comorbidity (87.7%); common comorbidities included sleep disturbance/insomnia [58.5%], depressive symptoms [51.9%], headache/migraine [46.2%], and anxiety [45.3%]. Mean (SD) pain severity score was 6.0 (1.77). Outcomes were worse among subjects with greater pain for health status, function, and sleep. Overall, 23.6% of subjects were employed for pay; 32.1% reported being disabled due to CLBP-NeP. Among those employed, lost productivity due to CLBP-NeP (62.3% overall work impairment) was substantial. Nearly all (98.1%) subjects were prescribed one or more medications for CLBP-NeP, including opioids (81.1%), muscle relaxants (33.0%), and antiepileptics (28.3%). Mean adjusted annualized direct and indirect costs per subject were $8,305 and $30,496 (mild), $10,189 and $26,428 (moderate), and $11,880 and $25,051 (severe), respectively, with no significant differences observed.


Patient and economic CLBP-NeP burden is high despite active management. Sub-optimal outcomes were associated with greater pain severity. Findings point to unmet need and indicate CLBP-NeP burden is experienced in terms of poor function and lost productivity.

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version