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Carrier Frequency of Congenital Leptin Deficiency in Central Punjab Region of Pakistan | OMICS International | Abstract
ISSN: 2165-7904

Journal of Obesity & Weight Loss Therapy
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Research Article

Carrier Frequency of Congenital Leptin Deficiency in Central Punjab Region of Pakistan

Muhammad Wasim* and Nida Fakhar
Institute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences Lahore, Pakistan
Corresponding Author : Muhammad Wasim
Institute of Biochemistry and Biotechnology
University of Veterinary and Animal Sciences, Lahore, Pakistan
Tel:923224990977
E-mail: [email protected]
Received date: March 24, 2015; Accepted date: April 25, 2015; Published date: April 30, 2015
Citation: Wasim M, Fakhar N (2015) Carrier Frequency of Congenital Leptin Deficiency in Central Punjab Region of Pakistan. J Obes Weight Loss Ther 5:260. doi:10.4172/2165-7904.1000260
Copyright: © 2015 Wasim M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Congenital leptin deficiency is a rare autosomal recessive disorder, characterized by hyperphagia and early onset obesity. Worldwide data on this disorder includes only 25 cases out of this only six pathogenic mutations have been reported in the leptin gene. Most of these cases have been reported in Central Punjab region of Pakistan, harboring a (p.Gly133fsX145) mutation in homozygous state. This mutation has founder effect in Arain caste from Central Punjab region of Pakistan. In this study, carrier frequency of (p.Gly133fsX145) mutation was determined in 50 individuals belonging to Arain caste. Analysis of amplicons contains p.Gly133fsX145 mutation were analyzed by different techniques such as SSCP, Heteroduplex analysis and sequencing. Mutation was not found in any individual studied. This finding suggests that frequency of (p.Gly133fsX145) mutation in Arain caste is not as higher as its predicted founder effect in congenitally obese children of this caste was anticipated.

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Citations : 1473

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