alexa Case Reports 0n Patients with Migraine Responding to Ozone Therapy
ISSN: 2167-0846

Journal of Pain & Relief
Open Access

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Case Report

Case Reports 0n Patients with Migraine Responding to Ozone Therapy

Dario Apuzzo1 and Paolo Ferrazza2,3*

1Centro di Recupero e Rieducazione Funzionale “SALUTE OK” Rome - Italy

2Centro Ricerca e Sviluppo Salute OK Rome - Italy

3Centro Ricerche Cliniche LNage S.r.l, (Link Neuroscience and Health care) Rome - Italy

*Corresponding Author:
Ferrazza P
Centro Ricerche Cliniche LNage S.r.l
(Link Neuroscience and Health care)
Via Luigi Rizzo, 62, Rome-00136, Italy
E-mail: [email protected]

Received February 28, 2016; Accepted May 30, 2016; Published June 03, 2016

Citation: Apuzzo D, Ferrazza P (2016) Case Reports 0n Patients with Migraine Responding to Ozone Therapy. J Pain Relief 5:252. doi:10.4172/2167-0846.1000252

Copyright: © 2016 Apuzzo D. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Background: Migraine is a proceeding or an episodic neurological disorder characterized by recurrent headache, moderate to severe, often in association with a series of symptoms of autonomic nervous system. Approximately 14% of the population suffer from this pathology with a peak incidence between 25 and 55 years of age. In addition, headache is very common in children and adolescents, particularly among teenagers whose prevalence is estimated around 8-23%. Case results: This report focuses on two cases with recurrent migraine episodes, different for sex and age, that shows the effectiveness of oxygen-ozone therapy also using two different modalities of ozone administration. In both of the cases, a drastic reduction in the frequency and intensity of pain with a consequent reduction in disability and an improvement in some health-related quality of life aspects was observed. Discussion: A greater number of patients are required to establish the efficacy and tolerability of ozone therapy in headache disorder, for which it is intended a treatment with anti-inflammatory drugs, often also toxic and with adverse effects.


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