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Hindi Effects of Probiotics on Intermediate Disease Markers in Individuals with Overweight and Obesity: Systematic Review and Meta-Analysis
*Corresponding Author:Received Date: Apr 15, 2024 / Published Date: Apr 14, 2025
Citation: Wu X, Peng C, Gou H, Le Q (2025) Effects of Probiotics on Intermediate Disease Markers in Individuals with Overweight and Obesity: Systematic Review and Meta-Analysis. Diagnos Pathol Open 10: 252.
Copyright: &Copy; 2025 Wu X, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
Abstract
Background: Overweight and obesity has become a global health issue with an increasing prevalence worldwide. Probiotics has shown its effectiveness on intermediate disease markers, however, its efficacy remain unclear. This meta-analysis examined the effects of probiotics on intermediate disease markers in individuals with overweight and obesity.
Methods: All randomized controlled trials published in the PubMed, Embase, Cochrane Library, and Web of Science databases between 2013 and 2023 were systematically searched. The Cochrane handbook risk of bias assessment tool was used to assess study quality. 26 studies with 1,884 adults with overweight and obesity were selected for inclusion in our analysis. Data were analyzed using the review manager 5.3 and Stata version 15.1 software.
Results: Probiotics significantly reduced Low-Density Lipoprotein (LDL) (MD=-0.1, 95% CI: -0.20, 0.00, p<0.05) and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) (MD=-0.17, 95% CI: -0.32, -0.01, p<0.05) and increased High-Density Lipoprotein (HDL) (MD=0.11, 95% CI: 0.01, 0.21, p<0.05). There were no significant changes observed in the levels of triglycerides, total cholesterol, fasting glucose, glycated hemoglobin, blood pressure and C-reactive protein (p>0.05).
Conclusion: Our results of this meta-analysis suggests that adding probiotics may be helpful for improving intermediate disease markers, such as LDL, HOMA-IR and HDL, in overweight and obese individuals. However, more high-quality studies are needed to confirm these findings.
