alexa Herba Swertiae Benefits the Gastrointestinal System In Vivo
ISSN: 2168-9652

Biochemistry & Physiology: Open Access
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Research Article

Herba Swertiae Benefits the Gastrointestinal System In Vivo

Xiang-Dong Han1, Guo-Wen Li2, Lian-Yu1, Han-Qi Jia1, Hang-Cheng Ye1, ZhiWei Zhou3, Yu-Hu Li1* and Guang Ji1*
1School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China
2Shanghai TCM-INTEGRATED Hospital, Shanghai University of TCM, Shanghai, China
3College of Pharmacy, University of South Florida, Tampa,FL, USA
Corresponding Authors : Yu-Hu Li
Shanghai University of Traditional Chinese Medicine
Shanghai, China
Tel: +86 21 5132 2049
Fax: +86 21 5132 2049
E-mail: [email protected]
  Guang Ji
Shanghai University of Traditional Chinese Medicine
Shanghai, China
Tel: +86 21 5132 2001
Fax: +86 21 5132 2000
E-mail: [email protected]
Received January 18, 2016; Accepted February 23, 2016; Published March 01, 2016
Citation: Han XD, Li GW, Yu L, Jia HQ, Ye HC, et al. (2016) Herba Swertiae Benefits the Gastrointestinal System In Vivo. Biochem Physiol 5:201. doi: 10.4172/2168-9652.1000201
Copyright: © 2016 Han XD, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Due to the increasing usage of herbal medicines and natural products for the body function management and ailments treatment and the lack of study on the beneficial effect of Herba Swertiae, a widely used traditional herbal medicine, this paper aimed to investigate the effect of Herba Swertiae on gastrointestinal system in vivo. The effect of Herba Swertiae on gastric emptying and intestinal propulsion was examined in mice; the effect of Herba Swertiae on gastric acid secretion and pepsin activity was tested in rats; and the effect of Herba Swertiae on the mobility of ileum was evaluated by ex vivo experiments using isolated ileum from guinea pig. The results showed that Herba Swertiae markedly enhanced gastric emptying and intestinal propulsion in mice. Also, Herba Swertiae remarkably increased the gastric acid secretion, the acidity of gastric acid, and the activity of pepsin in rats. Of note, these effects were comparable to that of positive control. Moreover, Herba Swertiae exerted a potent promoting effect on the mobility of ileum of guinea pigs, with a marked increase in the muscular tension force and contraction amplitude in the isolated ileum. Moreover, Herba Swertiae excited the isolated ileum that was inhibited by atropine. Taken together, Herba Swertiae exerts markable beneficial effects on gastrointestinal system in vivo. More studies are warranted for the investigation of the underlying mechanisms for its beneficial effects.

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