Immunology: Current Research
Open Access

Inflammasomes in Cancer Caused by Inflammation

Peter James^*

Department of Orthopaedic Surgery, Institute for Biomedical Engineering, Eberhard Karls University Tubingen, Tubingen, Germany

Received Date: Jul 07, 2022 / Published Date: Aug 04, 2022

Citation: James P (2022) Inflammasomes in Cancer Caused by Inflammation. Immunol Curr Res, 6: 124.DOI: 10.4172/icr.1000124

Copyright: © 2022 James P. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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An essential multiprotein complex known as the inflammasome is involved in inflammatory immunological responses. The autoactivation of caspase-1 and subsequent cleavage of proIL-1β and proIL-18, which are important sources of inflammatory symptoms, will occur as a result of inflammasome activation. On the other hand, inflammasomes also have anticancer properties through the regulation of the immune system and a specific type of programmed cell death known as pyroptosis. The final immunological effects are significantly influenced by the phases and compartments in which inflammasomes are activated. We provide a comprehensive overview of the roles played by inflammasomes in malignancies brought on by inflammation, particularly gastrointestinal and skin cancers. Additionally, information is provided about the inflammasome-related items' existing therapeutic uses and potential future research avenues [1].