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Intrathecal Morphine Therapy for Chronic Non-malignant Pain Using a Constant Flow Infusion System | OMICS International | Abstract
ISSN: 2167-0846

Journal of Pain & Relief
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Research Article

Intrathecal Morphine Therapy for Chronic Non-malignant Pain Using a Constant Flow Infusion System

Jairo Angelos, Martin Paiz, Christiane Pellegrino Rosa, Roberta Risso, Bernardo Monaco, Kleber Paiva Duarte, William Omar Contreras Lopez, Manoel Jacobsen Teixeira and Erich Talamoni Fonoff*
Pain Center and Division of Functional Neurosurgery, Department of Neurology, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
Corresponding Author : Erich Talamoni Fonoff
Division of Functional Neurosurgery
Hospital das Clínicas, University of São Paulo
Rua Dr Ovídio Pires de Campos
785, São Paulo, SP, Brazil, 01060-970
Tel: +55 11 2661 6402
Fax: +55 11 2661 6402
E-mail: [email protected]
Received November 25, 2014; Accepted December 30, 2014; Published January 02, 2015
Citation: Angelos J, Paiz M, Rosa CP, Risso R, Monaco B, et al. (2015) Intrathecal Morphine Therapy for Chronic Non-malignant Pain Using a Constant Flow Infusion System. J Pain Relief 4:168. doi: 10.4172/2167-0846.1000168
Copyright: © 2015 Angelos J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.


Background: Implantable pumps for intrathecal opioid therapy in the last decades emerged as one of the most effective treatment for chronic non-malignant pain (CNMP) in selected patients. This study analyses reliability of intrathecal infusion morphine therapy for chronic and refractory pain not related to malignancy using an implantable constant flow pump.

Methods: we studied eleven patients (9 women and 2 men; age range 26-67 years), with medically unresponsive CNMP. Pain was classified as neuropathic or non-neuropathic based on clinical features. Patients were evaluated before and after pump implantation, measuring pain intensity and relief after intrathecal opioid treatment based on Visual Analogic Scale (VAS) scores.

Results: Pain significantly reduced in almost all patients (91%); mean pain scores improved from 8.9 ± 1.49 before implant to 66% improvement one month after infusion therapy (3.1 ± 1.60) and 41% after 18 months (5.2 ± 2.45).

Conclusion: The present data show that intrathecal morphine infusion at a constant flow proved to be a safe and suitable alternative for the treatment of CNMP.


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