alexa Sensitive Spectrophotometric and Conductometric Methods
ISSN: 2168-9652

Biochemistry & Physiology: Open Access
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Research Article

Sensitive Spectrophotometric and Conductometric Methods for the Determination of Candesartan Using Acidic Dyes

Alaa S Amin1*, Hanna M Salah2, Gamal H Ragab2 and Inass S Kamel2
1Chemistry Department, Faculty of Science, Benha University, Benha, Egypt
2Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
*Corresponding Author : Alaa S. Amin
Chemistry Department, Faculty of Science
Benha University, Benha, 2345, Egypt
Tel: 0020105090599
Fax: 0020132222578
E-mail: [email protected]
Received February 25, 2015; Accepted March 06, 2015; Published March 13, 2015
Citation: Amin AS, Salah HM, Ragab GH, Kamel IS (2015) Sensitive Spectrophotometric and Conductometric Methods for the Determination of Candesartan Using Acidic Dyes. Biochem Physiol 4:153. doi:10.4172/2168-9652.1000153
Copyright: © 2015 Amin AS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Two simple, sensitive, accurate, rapid spectrophotometric and conductometric methods were developed for the determination of candesartan (CAND) in raw material and in its pharmaceutical preparation. The proposed methods depend upon the reaction of bromocresol green (BCG) or bromocresol purple (BCP) with candesartan in phosphate buffered solution to form stable colored ion-pair complex, which was extracted in chloroform. The yellow colored complexes were determined at λmax 415, 405 nm with BCG, BCP, respectively. Using conductometric titration, candesartan could be evaluated in acetone. The optimizations of various experimental conditions were described. The results obtained showed good recover of 100.14 (n=6) with relative standard deviation of 0.62 (n=6). Applications of the proposed methods to representative pharmaceutical formulations are successfully presented compared with official methods.

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