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Subjects with Knee Osteoarthritis Exhibit Widespread Hyperalgesia to Pressure and Cold | OMICS International | Abstract
ISSN: 2167-0846

Journal of Pain & Relief
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Research Article

Subjects with Knee Osteoarthritis Exhibit Widespread Hyperalgesia to Pressure and Cold

Penny Moss*, Emma Knight and Anthony Wright
School of Physiotherapy and Exercise Science, Curtin University of Technology, Perth, Australia
Corresponding Author : Penny Moss
School of Physiotherapy and Exercise Science
Curtin University of Technology
GPO Box U1987, Perth 6845, Australia
Tel: +61 8 9266 3668
Fax: +61 8 9266 3699
E-mail: [email protected]
Received: December 20, 2014 Accepted: October 31, 2015 Published: November 02, 2015
Citation: Moss P, Knight E, Wright A (2015) Subjects with Knee Osteoarthritis Exhibit Widespread Hyperalgesia to Pressure and Cold. J Pain Relief 4:210.doi:10.4172/21670846.1000210
Copyright: © 2015 Moss P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Hyperalgesia to mechanical and thermal stimuli are characteristics of a range of disorders such as tennis elbow, whiplash and fibromyalgia. This study evaluated the presence of mechanical and thermal hyperalgesia in individuals with knee osteoarthritis (OA), compared to healthy control subjects. Twenty-three subjects with knee OA and 23 healthy controls, matched for age, gender and BMI, were recruited for the study. Volunteers with any additional chronic pain conditions were excluded. Pain thresholds to pressure (PPT), cold (CPT) and heat (HPT) were tested at the knee, ipsilateral heel and elbow, in randomized order, using standardised methodology. Significant between-groups differences for PPT and CPT were found: OA subjects demonstrated significantly increased sensitivity to both pressure (p=0.018) and cold (p=0.003), but not to heat (p=0.167) stimuli, compared with controls. A similar pattern of results extended to the pain-free ipsilateral ankle and elbow indicating widespread pressure and cold hyperalgesia. This study found widespread elevated pain thresholds in subjects with painful knee OA, suggesting that altered nociceptive system processing may play a role in ongoing arthritic pain for some patients.