Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar
The Azole Menace: The Dark Side of Azoles Revealed | OMICS International | Abstract

Immunology: Current Research
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

The Azole Menace: The Dark Side of Azoles Revealed

*Corresponding Author:

Copyright: © 2019  . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

To read the full article Peer-reviewed Article PDF image


Background: The Epidemic of antifungal therapeutic failures (AFTF) against superficial mycotic infections, especially dermatophytosis is expanding at a rapid pace across South Asia and beyond. Although the abuse of topical steroids, inadequate dose/duration of therapy, and ignorance of other important epidemiological and personal factors are contributory, perhaps the strongest reason is the AZOLE MENACE, relatively unknown and ill-understood phenomenon. In this lecture, I shall dwell upon objectively on how the indiscriminate use of azoles, in particular, oral itraconazole is responsible for this regional epidemic that is threatening to become a pandemic lest urgent rectification is undertaken.

Unknown Facts Revealed: In this lecture some of the many azolerelated issues will be revealed with evidence-backed data.

• Patients with tinea visiting a dermatologist are not naive, rather polypharmacy-abused in more than 90% cases, having received multiple antifungals especially oral itraconazole/ topical azoles.

• Oral itraconazole is often injudiciously prescribed by primary care physicians in an inadequate dose/ duration or as multiple intermittent/ prolonged courses.

• The bioavailability/ serum levels of itraconazole are influenced by at least 15+ inconsistent factors

a. Around 54.3% Indians above the age of 45 years are on antacid medications like PPI’s, resulting in reduced bioavailability of itraconazole when co-administered. The effects of longer acting PPI’s like esomeprazole may persist up to 4-5 days.

b. Dependent on intake post meals and the effect of aerated drinks.

c. Serum levels affected by drug brand and pellet size.

• The sub-inhibitory concentrations of itraconazole achieved in patient’s serum significantly increase the likelihood of secondary azole resistance by selection pressure, since azoles being fungistatic allow persistence of organisms.

• The selection pressure-induced secondary resistance resulting from oral itraconazole is also seen to perpetuate pan-triazole and partial terbinafine and amorolfine resistance. Ciclopirox olamine is the only drug without a propensity to develop resistance.

• Itraconazole-resistant strains show high levels of cross-resistance to multiple triazoles including voriconazole and posaconazole, and often to six triazole fungicides used extensively in agriculture, qualifying for multi-triazole resistance (MTR).

• Azole-resistant fungi are more virulent because of the differences in cell wall composition, increased filamentation and adherence, and enhanced biofilm formation. Once acquired, resistance is maintained even in the absence of drug.

• Primary azole resistance due to their widespread use as agricultural fungicides, further adds to the azole menace. This phenomenon, which started from the Netherlands and rapidly engulfed majority of the European Union, has now reached the shores of the Indian Ocean. As per the statistics available from the website of Indian Ministry of Agriculture, in the 4-year.

• period from 2012 to 2016, there was an estimated 29.5% decrease and 34.2% increase in the consumption of insecticides and fungicides respectively

• The spreading azole resistance in superficial fungal infections resulting in selection of a population of mutants that don’t respond to any drug is likely to have graver ramifications in invasive dermatophytosis in immunocompromised individuals.


Recommended Conferences
Google Scholar citation report
Immunology: Current Research peer review process verified at publons
Indexed In
  • Publons
Share This Page