alexa 3, 3-Diindolylmethane Inhibits RAS/PI3K/AKT Signaling Through GPR30 Abrogate Cell Proliferation By BPA Induced Female Sprague Dawley Rats
ISSN: 2476-2067

Toxicology: Open Access
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

8th World Congress on Toxicology and Pharmacology
April 13-15, 2017 Dubai, UAE

S Thilagavathi and P Pugalendhi
Annamalai University, India
ScientificTracks Abstracts: Toxicol Open Access
DOI: 10.4172/2476-2067.C1.002
Abstract
The present study was aimed to evaluate the antiestrogenic effect of 3, 3 –diindolylmethane (DIM) on bisphenol A (BPA) induced alteration in estrogen signaling pathway in mammary glands of female Sprague-Dawley rats. BPA (10 μg/kg/bw) administered rat mammary tissues western blot analysis shows an over expression of GPR30, Ras, Src, PI3K and Akt proteins and immunohistochemical analysis indicates an over expression of PCNA and no significant changes in ERs. Further, oral administration of DIM (5 mg/ kg/bw) to BPA treated rats alternative days for the period of 12 weeks reveals that significant decrease in the expression pattern of GPR30, Src, Ras, PI3K, Akt and PCNA as compared to BPA alone treated rats. The results of our study demonstrate that BPA induces rapid action via the over expression of proteins in nongenomic estrogen signaling pathway. Oral administration of DIM to BPA treated group inhibits rapid action of BPA by modulating the proteins of nongenomic estrogen signaling pathway.
Recent Publications :
• Thangarasu Rajakumar, Pachaiappan Pugalendhi, Subbaiyan Thilagavathi (2015) Dose response chemopreventive potential of allyl isothiocyanate against 7,12-dimethylbenz(a)anthracene induced mammary carcinogenesis in female Sprague-Dawley rats. Chemico-Biological Interactions 231: 35–43.
Biography

S Thilagavathi is a PhD Research Scholar working on Cancer Biology of in vivo model.

Email: [email protected]

image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords