Ameliorative Effect Of Some Natural Products On Hepatic And Renal Functions In Female Mice Bearing Cancerous Tumor | 63589
Journal of Biotechnology & Biomaterials
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Curcumin and tannic acid which are naturally occurring dietary polyphenols, have exerted and found to be chemo-preventative
against cancer in various animal models. This study was carried out on 220 (12-14 weeks old, 25-30 g each) female mice. Mice
were classified into two main large experiments. Experiment 1: Non-tumor bearing mice (NTB) included 100 animals and divided
into four groups, each one comprised 25 mice. Group 1: NTB- control saline treated. Group 2: NTB-treated with curcumin orally
(350 mg/kg/day) for 6 weeks. Group 3: NTB-treated with tannic acid orally (160 mg/kg/day) for 6 weeks. Group 4: NTB-treated with
curcumin and tannic acid orally at ratio (50%:50%) for 6 weeks. Experiment 2: Tumor bearing (TB) mice. The total 120 animals were
divided into four groups, each one comprised of 30 mice. Group 1: TBM-control saline treated. Group 2: TBM-treated with curcumin
orally (350 mg/kg/day) for 6 weeks. Group 3: TBM-treated with tannic acid orally (160 mg/kg/day) for 6 weeks. Group 4: TBM-treated
with curcumin and tannic acid orally at ratio (50%:50%) for 6 weeks. Blood samples were collected from all animal groups after 2,
4 and 6 weeks from treatment. Serum were separated and processed directly for glucose, insulin, total cholesterol, triacylglycerol,
total protein determination. The obtained results revealed that, a highly significant decrease in serum glucose, total cholesterol, total
protein concentration, meanwhile, a highly significant increase in serum triacylglycerol concentration was also observed. But a nonsignificant
decrease in serum insulin levels were observed in tumor bearing mice when compared with control. The results of this
study indicated that curcumin, tannic acid and their combination treatment have potential benefits in cancer treatment.
Mohammed F El-Shiekha has completed his PhD from the Department of Biochemistry, Faculty of Veterinary Medicine, Benha University, Egypt. He is a Faculty Member in the Department of Biochemistry and pharmacy in October 6 University, Egypt. He has published 6 papers in reputed journals.