alexa
Reach Us +19473334405
Ameliorative Effect Of Some Natural Products On Hepatic And Renal Functions In Female Mice Bearing Cancerous Tumor | 63589
ISSN: 2155-952X

Journal of Biotechnology & Biomaterials
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Recommended Conferences

23rd Global Congress on Biotechnology

London, UK

International Conference on Biotechnology and Healthcare

Auckland, New Zealand
Share This Page

Ameliorative effect of some natural products on hepatic and renal functions in female mice bearing cancerous tumor

Joint Event on 15th World Congress on Biotechnology And Biotech Industries Meet and 2nd International Conference on Enzymology and Molecular Biology

Mohammed F. EL-Shiekha

October 6 University, Egypt

Posters & Accepted Abstracts: J Biotechnol Biomater

DOI: 10.4172/2155-952X.C1.071

Abstract
Curcumin and tannic acid which are naturally occurring dietary polyphenols, have exerted and found to be chemo-preventative against cancer in various animal models. This study was carried out on 220 (12-14 weeks old, 25-30 g each) female mice. Mice were classified into two main large experiments. Experiment 1: Non-tumor bearing mice (NTB) included 100 animals and divided into four groups, each one comprised 25 mice. Group 1: NTB- control saline treated. Group 2: NTB-treated with curcumin orally (350 mg/kg/day) for 6 weeks. Group 3: NTB-treated with tannic acid orally (160 mg/kg/day) for 6 weeks. Group 4: NTB-treated with curcumin and tannic acid orally at ratio (50%:50%) for 6 weeks. Experiment 2: Tumor bearing (TB) mice. The total 120 animals were divided into four groups, each one comprised of 30 mice. Group 1: TBM-control saline treated. Group 2: TBM-treated with curcumin orally (350 mg/kg/day) for 6 weeks. Group 3: TBM-treated with tannic acid orally (160 mg/kg/day) for 6 weeks. Group 4: TBM-treated with curcumin and tannic acid orally at ratio (50%:50%) for 6 weeks. Blood samples were collected from all animal groups after 2, 4 and 6 weeks from treatment. Serum were separated and processed directly for glucose, insulin, total cholesterol, triacylglycerol, total protein determination. The obtained results revealed that, a highly significant decrease in serum glucose, total cholesterol, total protein concentration, meanwhile, a highly significant increase in serum triacylglycerol concentration was also observed. But a nonsignificant decrease in serum insulin levels were observed in tumor bearing mice when compared with control. The results of this study indicated that curcumin, tannic acid and their combination treatment have potential benefits in cancer treatment.
Biography

Mohammed F El-Shiekha has completed his PhD from the Department of Biochemistry, Faculty of Veterinary Medicine, Benha University, Egypt. He is a Faculty Member in the Department of Biochemistry and pharmacy in October 6 University, Egypt. He has published 6 papers in reputed journals.

Email: [email protected]

Top