Analysis Of Cancer-testis Antigens As Molecular Drug Targets Using Network Pharmacology | 38945
Journal of Biotechnology & Biomaterials
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Present chemotherapeutic drugs have limited efficacy and sever side effects. Considering the complexity of cancer, an
effective strategy is to discover multiple new drug targets. Cancer testis antigens are vital of cancer cell progression and
drugs targeting these proteins should have no toxicity. We have performed network analysis of cancer testis antigens and
assessed nodes as drug targets based on its position in the network. We have analyzed the protein interaction network of
700 human CT antigens based on available information on STRING 9.1 database. CT antigen network consisted of eight
independent components. Four major hubs and two minor were identified that play nodal role in flow of information across
the largest network. We have predicted 30 potential drug targets by analyzing topological parameters such as betweenness
centrality, cluster coefficient and probable protein complexes. Structural and functional roles of potential drug targets were
analyzed. Analysis of CT antigen network enables us to identify a set of candidate proteins that if targeted could be detrimental
for cancerous cell without affecting any normal cell. The list of putative proteins is a starting point for experimental validation
and further discovery of new anti-cancer drugs.
Anuj Kumar has completed his PhD under the supervision of Dr. Amit Sharma, ICGEB, JNU and completed his Postdoctoral studies with Dr. Chetan E. Chitnis, Malaria Biology Group, ICGEB. He is currently working as Head of Molecular Biology Lab in Shriram Institute for Industrial Research, Delhi.