Antiplasmodial Activity Of Biosynthesis Nanoparticles From Seaweeds Plasmodium Falciparum | 50606
Journal of Infectious Diseases & Therapy
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Malaria is one of the most prevalent infectious diseases in the world. Treatment for malaria is commonly inadequate due to the
lack of quality assured effective drugs. The effectiveness of these drugs is declining at an ever accelerating rate with consequent
increase in malaria related morbidity and mortality. The newest antiplasmodial drug from plants is needed to overcome this problem.
The seaweeds species are a good source of bioactive entities which exhibits many therapeutic properties. The present study was carried
out to test the antiplasmodial activity of three seaweeds species distributed along the South East coast of India. Biosynthesis silver
nanoparticles from Sargassum sps Caulerpa taxifolia and Dictyota dichotoma plant exhibited in vitro antiplasmodial activity against
Plasmodium falciparum. Of which, the nanoparticles of D. dichotoma exhibited high antiplasmodial activity (IC50=60.11 μg.ml−1).
Statistical analysis reveals that, significant antiplasmodial activity (P<0.05) was observed between the concentrations and time of
exposure. The chemical injury to erythrocytes was also carried out and it shows that no morphological differences in erythrocytes
by the synthesized nanoparticles of seaweeds after 48 hours of incubation. The FTIR results of most potent leaf extract-synthesized
silver nanoparticles showed the prominent peaks (range between 620.967 to 2854.14) Further, the results of XRD analysis showed
the 2 hours intense values (38.11 and 70.57) within the ranges of Bragg’s reflection. In addition, the SEM analysis showed the results
of particle sizes (50-100 nm). This study shows that the biosynthesized silver nanoparticles had a source of lead compounds for the
development of new drugs for the treatment of malaria.
Syed Ali M is now currently working as the Head of the department and Research Department of Biotechnology at Mohamed Sathak College of Arts and Science (Affiliated to University of Madras), Chennai, India. He had completed Phd in Oceanography – Marine Biotechnology 2011 (Title: Screening of various biological resources from Gulf of Mannar for the management of Dengue fever) and also Master of Philosophy and Master of Science in Marine Biotechnolgy, 2006. He had published 4238 international publication in peer reviewed journals and also contributed three book chapter. He is the member of five scientific committee to all over the world especially European Society of Clinical Microbiology and Infectious Disease, Europe (Member ID: 123822) and Advisory Board Member of all of the world.