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Approaches To Lead Generation - A Novel Molecular Target In Cancer Drug Discovery Development | 4855
Journal of Biotechnology & Biomaterials
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Cell regulation is an essential mechanism in cell proliferation and has close relationship with carcinogenesis.The main focus
in cancer research is on the formation, activation, inactivation,of Cyclin ? CDK(Cyclin Dependent Kinase) complex which
forms the basis of cell regulation (1).Cyclin X1 is a new member of cyclin family which is located in nucleus, whose expression is
induced by DNA damageand is transcriptionally activated by P53 tumour suppressor gene (2). CyclinX1 exerts a negative feedback
regulation of P53 by regulating dephosphorylation of Mdm2, an Oncoprotein, by complexing with PP2A during nucleolar stress.
(3,4). The main objective is to inhibit the binding of PP2A- Mdm2 complex (5)and with cyclin X1 which stabilizes P53 leading to
cellcycle arrestor apoptosis.
In the present work, the 3D model of cyclin X1is generated using homology modeling techniques and validation protocols.
Active site prediction is carried out using various server tools and Schrodinger Suite, which allow envisaging the important
pockets for putative receptor binding.(6,7,8).Further studies are aimed at designing new chemical entities which may be used as
potent anti cancer therapeutic leads.
P. Sarita Rajender, DST ? Scientist at The Department of Chemistry, Nizam College, Osmania University since 2009 and has completedPh.D in
Synthetic Organic Chemistry in the year 1996. She is a post-doctoral research fellow working on novel platforms for finding new leads in Cancer
therapy. Patenting process is under progress for promising new lead molecules. Her field of research interest includes modeling of novel protein
targets & identification of new chemical entities (NCE?s) using Computational Chemistry, Chemical-Biology and Software tools. She has mentored
PG students in their dissertation workduring teaching tenure. She has actively involved in organizing seminars/ workshop for students. Dr. P.
SaritaRajender published several research articles in reputed international journals and has presented papers at various International and National
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