alexa Ascochlorin Acts As An Anti-inflammatory Agent In LPS-stimulated RAW264.7 Macrophages:Downregulation Of COX-2 And INOS Through Suppression Of ERK, JNK And P38 MAPK
ISSN: 2155-952X

Journal of Biotechnology & Biomaterials
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5th World Congress on Biotechnology
June 25-27, 2014 Valencia Conference Centre, Valencia, Spain

Sook-Hyun Lee, Choong-Hwan Kwak, Sun-Hyung Ha, Seok-Jong Suh and Cheorl-Ho Kim
Posters: J Biotechnol Biomater
DOI: 10.4172/2155-952X.S1.028
Inflammation is involved in numerous diseases such as cancer, intestinal inflammation and diabetes. Ascochlorin (ASC) is isolated from an incomplete fungus, Ascochytaviciae andknown to have an antibiotic and antifungal activity. However, anti- inflammatory effect in lipopolysaccharide (LPS)-induced murine macrophages RAW 264.7 by ASC is unclear.In this study, data showed that ASC significantly suppressed the production of nitric oxide (NO) in LPS-stimulated RAW 264.7 cells. And ASC also decreased expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in protein levels as well as mRNA levels in a dose-dependent manner. Furthermore, ASC also suppressed LPS-induced phosphorylation of mitogen activated protein (MAP) kinases.In addition, reduction of viability was observed after ASC treatments in raw 264.7 cells. And an up-regulation of Bax (BCL-2-associated X protein) and a down-regulation of Bcl-2 (B-cell lymphoma 2) were appeared that ASC promotes the apoptosis. These findings proposed that anti-inflammatory effects and apoptotic cell death by ASC lead to the immunosuppressive activity in RAW 264.7 cells.
Sook-Hyun Lee graduated from Food Science and Biotechnology Department, DongnamHealth College, Suwon, Korea in 2011. PresentlyMaster coursed student at the Molecular and Cellular Glycobiology Lab, Department of Biological Science, Sungkyunkwan University, Suwon, Korea under supervisor Prof. Cheorl-Ho Kim
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