Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers
Google Scholar citation report
Citations : 2154
Journal of Biotechnology & Biomaterials received 2154 citations as per Google Scholar report
Indexed In
- Index Copernicus
- Google Scholar
- Sherpa Romeo
- Open J Gate
- Genamics JournalSeek
- Academic Keys
- ResearchBible
- China National Knowledge Infrastructure (CNKI)
- Access to Global Online Research in Agriculture (AGORA)
- Electronic Journals Library
- RefSeek
- Hamdard University
- EBSCO A-Z
- OCLC- WorldCat
- SWB online catalog
- Virtual Library of Biology (vifabio)
- Publons
- Geneva Foundation for Medical Education and Research
- Euro Pub
- ICMJE
Useful Links
Recommended Journals
Related Subjects
Share This Page
In Association with
Asymmetrically porous nerve guide conduit with nerve growth factor gradient for effective peripheral nerve regeneration
10th Asia-Pacific Biotech Congress
Jin Ho Lee, T H Kim, J G Kang and S H Oh
Hannam University, South Korea Dankook University, South Korea
Posters & Accepted Abstracts: J Biotechnol Biomater
Abstract
Peripheral nerves function as communication paths between the brain and muscle/organ/skin and injury to these nerves leads to the severe loss of sensory or motor functions. Although the understanding of nerve regeneration and the development of surgical techniques are rapidly growing, sufficient restoration of damaged nerves still remains a big challenge. Recently, artificial nerve guide conduit (NGC) to bridge the gap between severed peripheral nerve stumps has been demonstrated to be a promising strategy for the treatment of damaged nerves. It is well known that the nerve regeneration is mediated by gradients of bioactive molecules including nerve growth factor (NGF; chemotaxis). In this study, the NGF gradient NGC was fabricated by rolling an asymmetrically porous polycaprolactone (PCL)/Pluronic F127 membrane with NGF gradient. The NGF loading amount and NGF release profile along the NGF gradient were investigated. The NGF immobilized on the NGC was continuously release up to 28 days, regardless of the NGF concentration. The nerve regeneration behaviors through the NGF gradient NGC were compared to the NGC with uniform NGF immobilization using a SD rat with a 2 cm long sciatic nerve defect. From the animal study, it was recognized that the NGF gradient NGC shows greater nerve regeneration behavior than the uniform NGF group. Based on our findings, it is suggested that the NGC with asymmetrically porous structure and gradient of NGF concentration can be a simple and effective therapeutic technique to accelerate the reinnervation rate and provide sufficient functional recovery of peripheral nerves.Biography
Jin Ho Lee was graduated from the University of Utah, USA with PhD degree in 1988. He has worked at Korea Research Institute of Chemical Technology (KRICT) as a Senior Research Scientist from 1988 to 1993. Since 1993, he is a Professor in Hannam University, Korea. He was a President of Korean Tissue Engineering and Regenerative Medicine Society (KTERMS) (2012). He was selected as a Fellow within the TERMIS in 2015. His recent research area includes stem cells/ biocompatible polymer hybrid materials (scaffolds, membranes, microparticles and hydrogels) for tissue regenerations such as cartilage, bone, tendon, muscle, trachea, vocal fold and nerves.
Email: jhlee@hnu.kr
