alexa AvidinOX-targeted Delivery: A New Way To Improve Efficacy Of Well-known Monoclonal Antibodies For Cancer Therapy | 63546
ISSN: 2155-952X

Journal of Biotechnology & Biomaterials
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Joint Event on 15th World Congress on Biotechnology And Biotech Industries Meet and 2nd International Conference on Enzymology and Molecular Biology
March 20-21, 2017 Rome, Italy

Rita De Santis
Sigma Tau SpA, Italy
Keynote: J Biotechnol Biomater
DOI: 10.4172/2155-952X.C1.069
Abstract
We recently discovered that the oxidized version of hen egg white avidin, named AvidinOX, can chemically link to tissue proteins when injected or nebulized, thus becoming an artificial receptor for biotinylated therapeutics. This product is currently under investigation in phase I clinical trials for targeting intravenously administered 177Lutetium-biotinDOTA to inoperable tumor lesions and liver metastases, pre-injected with AvidinOX (ClinicalTrials.gov NCT02053324). Several published and some non-published data from our group indicate that AvidinOX-targeted delivery of the biotinylated version of some marketed monoclonal antibodies turns non-effective doses of such antibodies effective for cancer treatment. Among the antibodies tested, AvidinOX-targeted delivery of biotinylated anti-EGFR cetuximab and panitumumab, and anti-ErbB2/ neu trastuzumab and pertuzumab were particularly effective. Molecular mechanisms explaining the improved anti-tumor activity of AvidinOX-anchored biotinylated antibodies have been also described by our group. Overall, our data provide a scientific rational for further pre-clinical and clinical investigation of therapeutic approaches based on the local delivery of AvidinOX (i.e., intra-tumor, aerosol or intra-peritoneal delivery) followed by local or systemic delivery of low dose biotinylated antibodies. The expectation of our AvidinOX-targeted delivery platform is to reduce the cost of cancer treatments and improve tolerability by reaching anti-tumor efficacy with significantly less amount of expensive antibodies.
Biography

Rita De Santis has a degree in Biological Sciences and PhD in Experimental Medicine from Rome University and National Institutes of Health, USA, respectively. Since 1999, she directs the group of Biotech Products at Sigma Tau SpA, leading innovative products from bench to clinical trials. She is the author of 70 papers and 20 patents. Her work focuses on the development of the AvidinOX-based therapeutic platform for cancer therapy and looking for collaborations to fully exploit the potential of AvidinOX for targeted delivery of biotinylated drugs in additional therapeutic fields.

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version