alexa Biodegradable Polyesters For Biomedical Applications: Alternatives To Polylactides And Polylactones
ISSN: 2155-952X

Journal of Biotechnology & Biomaterials
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

2nd Annual Conference and Expo on BIOMATERIALS
March 27-28, 2017 Madrid, Spain

Jose R Sarasua and Jorge Fernandez
University of the Basque Country, Spain
ScientificTracks Abstracts: J Biotechnol Biomater
DOI: 10.4172/2155-952X.C1.073
Abstract
Today’s medicine requires bio-absorbable polymeric biomaterials that present thermoplastic elastomer (TPE) behavior, for their application as medical devices or scaffolds for soft tissue engineering. Among the most investigated polymers used as biomaterials, poly (glycolic acid) (PGA) and poly (lactic acid) (PLA) can be mentioned. These polyesters are however glassy at body temperature and mechanically brittle, so copolymerization with other monomers is a strategy to obtain TPEs with tuned biodegradation rate and mechanical properties. In a search of new polymeric biomaterials with TPE behavior, various lactones and macro lactones, most of them were employed previously by the chemical industry and cosmetics, which draw our attention. Among the cyclic esters, the following ones can be mentioned: β-propiolactone (β-PL), γ-butyrolactone (γ-BL), γ-valerolactone (γ-VL), δ-valerolactone (δ- VL), δ-methyl-ε-caprolactone, decalactones such as γ-decalactone (γ-DL), δ-decalactone (δ-DL) or ε-decalactone (ε-DL) (with rings of 5, 6 or 7 members respectively), ω-pentadecalactone (PDL), hexadecalactone or ethylene brassylate. Moreover, p-dioxanone or trimethylene carbonate may also be of interest. The mentioned substances are monomers that can be synthesized by ring opening polymerization on their own or on the dimmer (lactide and glycolide). In this work TPE copolymers of either high glass transition temperature (Tg) (>20ºC ) or low Tg (between -65 and 0ºC) are synthesized and characterized in terms of molecular parameters, physical, chemical and mechanical properties and biodegradation. In the former case, copolymers of lactide with other co-monomers are proposed in order to reduce the melt temperature and crystallization capability of polylactide. In the latter, alternative copolymers will be introduced for poly (ε-caprolactone). This is because polymers of high Tg present low ductility, brittleness and too high stiffness for soft tissue applications. Those of low Tg, however, though excellent in the combination of mechanical properties for soft tissue engineering and devices, present often too low biodegradation rates.
Biography

Jose R Sarasua is Professor of Materials Science at the Department of Mining-Metallurgy Engineering and Materials Science, Faculty of Engineering of Bilbao, the University of the Basque Country (UPV/EHU). He is the Principal Investigator of the ZIBIO group on Science and Engineering of Polymeric Biomaterials and Member of POLYMAT, the Basque Center for Macromolecular Design and Engineering. His research interests are focused on the synthesis, structure and properties of polymeric biomaterials for medical applications.

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords