Carbapenem Resistant Mechanisms In Pseudomonas Aeruginosa: A Report From Iran | 105444
Journal of Infectious Diseases & Therapy
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Pseudomonas aeruginosa is one of most prevalent and important Gram negative bacteria in hospital can cause healthcare
association infection in hospitals. Multi Drug Resistance (MDR) strains for these microorganisms can create drastically
therapeutic challenges. During the last decade, first line antibiotic resistance using for the treatment of Gram negative bacterial
infections are increasing globally and in the recent decade resistant to beta-lactam antibiotics such as carbapenemas as a
broad spectrum antibiotic has become increasingly prevalent. Resistance associated with production of carbapenemase and
also, efflux pump are the important problem in the health care systems. Carbapenemase can hydrolyze all of beta- lactam
antibiotics except Monobactam in some case. Efflux pump can eject different classes of antibiotics to outside of bacteria and
make resistance to them. So, these two important antibiotic resistance mechanisms can lead to appearance of multi drug
resistance P. aeruginosa. This study reports the rate of different important carbapenemase and also increase of gene expression
in efflux pump in P. aeruginosa strains were isolated from some burden cities in Iran.
Shahnaz Armin is a Specialist of Pediatric Infectious Diseases in Pediatric Infections Research Center, Research Institute for Children Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Her research interest is in Medical Microbiology and also Antibiotic Resistance. Her research group works on national project about global threating bacteria according to priority of WHO.