Chemical Structure And In Vitro Antitumor Activity Of Trehalose Lipid Biosurfactant From A Novel Nocardia Farcinica Strain | 17286
Journal of Biotechnology & Biomaterials
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Recently, some biosurfactants were proved to be suitable alternatives to synthetic medicines and may be used as effective
theurapeutic agents, for example, certain trehalose lipids have been shown to possess properties of biomedical importance,
since they can act as anticancer and immunomodulating agents.Trehalose lipids are glycolipid biosurfactants produced by
most species belonging to the mycolates group such as Mycobacterium,
Rhodoccoccus, Arthrobacter, Nocardiaand Gordonia.
date there are very few studies carried out on the potential use of trehalose lipid biosurfactants as anticancer agents.The aim of
this study was to isolate and identify the chemical structure of a biosurfactant produced by a newly isolated
strain BN26, and evaluate its
antitumor activity on a panel of human cancer cell lines. Strain BN26 was found to
produce glycolipid biosurfactant on n-hexadecane as the sole carbon source. The biosurfactant was purified using medium
pressure liquid chromatography and characterized as trehalose lipid tetraester (THL) by nuclear magnetic resonance (NMR)
spectroscopy and mass spectrometry (MS). Subsequently, the cytotoxic effects of THL on cancer cell lines BV-173, KE-37
(SKW-3), HL-60, HL-60/DOX and JMSU-1 were evaluated by MTT assay. The results showed that THL caused concentration
dependent cytotoxicity on all human tumor cell lines investigated.
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