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Clinical Validation Of Diagnostic Imaging Procedures | 57205

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Clinical validation of diagnostic imaging procedures

International Conference on Medical Imaging & Diagnosis

Michael L Goris

Stanford University School of Medicine, USA

Keynote: OMICS J Radiol

DOI: 10.4172/2167-7964.C1.008

Abstract
When new imaging is introduced in clinical settings, little is known about their potential to improve care. Acceptance is mostly based on how well structures can be seen on the images. True clinical validations are perceived as time expensive and di cult to fund. In this paper we look for alternatives.  e de ning diagnosis (e.g. by histology, microbiology) is a type of taxonomy, but is that taxonomy related to outcome?  e validation of de ning diagnostic technique is solipsistic. We will look at: Outcome analysis: Since imaging represents only a few steps in a chain of diagnostic and therapeutic interventions, it is di cult to ascribe the outcome to any speci c link.  e performance of an imaging test may be excellent, but there may still be adverse outcomes; outcomes evaluations of imaging are rare. Predictive power: A taxonomic exact diagnosis may not be predictive. If the median survival time is n years: 50% percent die earlier, 50% later. Staging re nes the prognosis, or the expected response to a particular therapy. Imaging can predict if therapy will fail or succeed. Predicting taxonomy:  e most relevant aspect of this approach is that at some point there has to be a de ning test. Or that a ground truth is assumed to be known.  e major problem is veri cation bias in the  rst case.  ere are ways to overcome is veri cation bias. Discriminating power: It is the ability to distinguish between closely related populations in all aspects except the actual disease. Equivalence: It is based on the (false) assumption that a gold standard re ects the ground truth.  e result is the inability to show diagnostic superiority (no worse than). In conclusion, there are approaches to evaluate diagnostic imaging, which are both valid and not too expensive.
Biography

Michael L Goris has a Medical degree from the University of Leuven in Belgium and a PhD degree in Medical Physics from UC Berkeley. He has been a Professor in the Stanford Medical School and is Emeritus since 2012 and served as a Chairman for University panel on Radiation safety during 2003-2010. He has more than 120 publications in peer reviewed journals. His research interests are radio-immunotherapy, medical imaging processing and quantifi cation for diagnosis of clinical validations.

Email: mlgoris@stanford.edu

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