Cloning, Sequencing, Expression And Evaluation Of Efficacy Of The Antigen Devr (Msmeg_52440) In Serological Diagnostic Assays | 4921
Journal of Biotechnology & Biomaterials
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The DEVR response regulator in Mycobacterium tuberculosisis believed to play a key role in bacterial dormancy adaptation
during hypoxia. The presence of a homologous genetic system in Mycobacterium smegmatis was predicted by scanning its
genome sequence with DEVR of Mycobacterium tuberculosis. The similarity in sequences and hypoxia-responsive behavior of
DEVR in Mycobacterium smegmatis and Mycobacterium tuberculosis suggests that the molecular mechanisms involved in the
dormancy response are likely conserved in these two species and hence Mycobacterium smegmatis could therefore serve as a
useful model for studying and evaluating the immunogenic properties of antigen DEVR. In the present study we report efficacy
of antigen DEVR (MSMEG_5244) in serological diagnostic assays by determining the immunological reactivity of this protein.
This protein encoding ORF was cloned, sequenced, expressed in E.coli and the recombinant protein was purified.
S. Radha completed M.SC in Microbiology, M.TECH in Bioinformatics and now she is pursuing her PhD from Department of Genetics, Institute
of Basic Medical Sciences, university of Madras, Taramani, Chennai, India. She is currently working as Assistant Professor in Department of
Bioinformatics; Vels University, Chennai. She has published many articles in reputed journals.
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