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Design And Evaluation Of Oral Controlled Release Mucoadhesive Microspheres Of Didanosine | 4646
Journal of Biotechnology & Biomaterials
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The present work was carried out for targeted delivery of drug in a controlled manner in gastro-intestinal tract by mucoadhesion
and to reduce the dosing frequency .Formulation of Mucoadhesive Microspheres was carried out by taking Drug-Didanosine (anti- viral/BCS CLASS-
iii), along with polymers for muco-adhesion such as HPMC K4M and Carbopol 934P(F1andF2) respectively. The prepared microspheres were evaluated by various evaluation tests such as Determination of Particle size(F1-Average particle size was reported as 502?1.20 and F2 was 510?1.36, Swelling index was reported upto 8 hours with an interval of each one hour (Swelling
index reported after 8 hours for F1-0.82 and F2-0.96) , Drug content(F1 52.36 %w/v and F2 56.48 %w/v ),Entrapment efficiency(F1 52.36?0.21 and F2 56.48?0.36), In-vitro drug release studies(cumulative percentage release after 8 hr was 76.264% and 80.312% for F1 and F2) and In- vitro wash off test to assess Mucoadhesive properties of Microspheres (% mucoadhesion varied from F1 ?F2 after 6hr as 45%-38%).From these experimental results F2 showed maximum % yield.
K. Mani Madhuri is pursuing her M.pharm 1st year in Yalamarty college of pharmacy, Visakhapatnam and completed her B.Pharm in Roland Institute
of Pharmaceutical Sciences had published a review article on Mucoadhesive Drug Delivery System in APTI Convention and also presented a
research article in the National Seminar held in Bhuvaneswar.
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