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Design Of Aggregation Resistant Protein Biotherapeutics | 17119
Journal of Biotechnology & Biomaterials
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Protein biotherapeuticshas emerged as promising new drugs for human disorders. However, they are extremely sensitive
to stress, a major problem being the formation of aggregates during production and delivery, which impact the product
quality and produce adverse immunogenic reactions. Here the author introduces A3D, an evolution of the AGGRESCAN
algorithm, a new tool able to predict and assist the redesign of aggregation propensity in protein 3D-structures.
Salvador Ventura is Full Professor at the Department of Biochemistry and Molecular Biology and leader of the Protein Folding and Conformational Diseases group
at the Institute of Biotechnology and Biomedicine, Autonomous University of Barcelona (UAB). He has authored more than 110 peer-reviewed research and review
papers on protein folding and proteomics, apart from several book chapters and patents. He got his PhD in Biology at the UAB in 1998 and worked as postdoctoral
fellow (1999-2001) at EMBL-Heidelberg. He has been researcher at Harvard Medical School (USA) and KarolinskaInstitutet (Sweden) among other centres.
He rejoined UAB as a Ramon y Cajal researcher in 2003. He received the UAB 2008 Excellence Research Award and in 2009 the ICREA-Academia Award on
Biological and Medical Sciences.
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