Design Of New Leads As Novel Therapeutics For Tuberculosis - A Computational Approach | 4874
Journal of Biotechnology & Biomaterials
Like us on:
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Tuberculosis (TB) has been a global health threat currently affecting 9million new cases every year. In spite of chemotherapy
and BCG vaccine, Mycobacterium tuberculosis (MTB) is causing one death in every 10 seconds. Major challenges and
lacunae in the existing therapy are: prolonged therapy coupled with poor compliance of patients to drug administration and
adaptation of the pathogen to evolve into multidrug resistant (MDR) and extensively drug resistant (XDR) TB strains.
In view of the latest technological information about the genome of the MTB and the mechanism of MTB manifestation,
novel targets involved in various phases of life cycle of the bacteria may be considered for design of effective TB therapeutics. In
the present work, proteins involved in (a) Transcription (b) Dormant stage and (c) Multidrug resistance of MTB, are explored
for design of effective leads as antagonists for the mycobacterium pathogen. Computational techniques are applied to the targets,
for 3D structural evaluation, identification of active site and novel leads are designed using virtual screening against the active
site with molecular databases. Specific examples are presented and discussed. The study identifies new molecular entities for
Uma Vuruputuri is Professor at The Department of Chemistry, Nizam College, Osmania University since 1998. Her research interests include
Molecular Modelling and Drug Designing with special reference to the Identification of NME?s for the treatment of Cancer and Tuberculosis using
Insilco Techniques. Prof. Uma?s research group includes 10 Doctoral students, 8 Master?s and M. Pharmacy students working towards their Thesis
dissertation. She published several research papers in international peer reviewed Journals. Prof. Vuruputuri has reviewed several Research articles
of international Journals, in the field of Chemical Biology, Bio Informatics and Molecular Modelling. Currently, Prof. Uma Vuruputuri is working
on projects with special focus on Tuberculosis and Cancer, sponsored by DST and UGC, New Delhi, India. She is actively involved in academic
administration of Nizam College and is a Governing Body member of Nizam College She is a resource person for designing the curriculum for UG
and PG programs in the field of Pharmaco Informatics and Molecular modelling.
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals