Detection And Clinical Significance Of Sternal Lesions On Breast MRI | 57217
OMICS Journal of Radiology
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The purpose of this study is to characterize sternal lesions detected on breast MRI, compare MRI detection of sternal
lesions with other imaging modalities (bone scan, PET/CT and chest CT), and ascertain how often patient management
is altered by discovery of sternal lesions. Retrospective review of 1143 breast MRIs between 2007 and 2012 identified 17
patients with sternal lesions including 15 patients with newly diagnosed breast cancer and 2 patients with remote history of
breast cancer. Tumor size, histopathology, receptor status, nodal and distant metastasis, and images of breast MRI and other
modalities were reviewed. Sternal lesions in 9 of the 17 patients were determined to be malignant (metastasis) either by biopsy
or presence of widespread metastases. Sternal lesions in 8 of the 17 were benign, confirmed by biopsy or presumed benign as
not detected by other modalities. The malignant group had statistically significant larger breast cancer size (malignant: 6.4 cm;
benign: 2.3 cm), a higher percentage of diffuse sternal lesions (malignant: 56%; benign: 0%), and more frequently showed rapid
initial enhancing (malignant: 100%; benign: 63%) and delayed washout curves (malignant: 67%; benign: 13%). Although not
statistically significant, the malignant group had a higher frequency of invasive lobular carcinoma (malignant: 44%; benign:
13%) and more lymph node involvement (malignant: 78%; benign: 50%). Breast MRI detected more sternal lesions than did
bone scan, PET/CT and chest CT. Four of the 17 (24%) patients were upgraded to stage 4 due to unsuspected metastatic sternal
lesions on breast MRI. In conclusion, breast MRI is more sensitive than other modalities in detecting sternal lesions. Sternal
metastases occur more frequently in aggressive breast cancer and exhibit malignant-type dynamics on breast MRI. Detection
of unsuspected sternal metastasis alters staging and improves patient management with more appropriate treatment.
Limin Yang has completed her MD from Peking University Health Science Center, PhD and Post-doctoral training from The University of Texas Health Science Center at San Antonio. She completed her Radiology Residency and Breast Imaging Fellowship from The University of Iowa. She is a Clinical Associate Professor in the Department of Radiology, The University of Iowa and the Medical Director of Breast Imaging at The University of Iowa Hospitals and Clinics. She has published more than 20 papers in reputed journals and has been serving as an Editorial Board Member of Journal of Medical Diagnostic Methods and is reviewer for several reputed journals.