Journal of Biotechnology & Biomaterials
Open Access

Abstract

In this study, we intend to used self-condensation of an AB2 monomer to prepare fluorescent hyperbranched poly (amido acids) (HBPAAs) featuring wholly aliphatic backbones, multiple terminal CO2H units, and many internal tertiary amino and amido moieties. Because tertiary amino groups are known to behave as fluorescent centers in dendritic structures, in this study we wish to prepared AB2 monomer through an efficient synthetic scheme, involving blocking and deblocking processes, in high yield. Visible blue photoluminescence self-emissions would be generated from the non-conjugated HBPAAs in aqueous solution; that is, bright blue fluorescence behavior, with emission peaks at 395 nm and fluorescence QYs of up to 23%, appeared when the branching tertiary amino moieties were embedded in a self-polymerized globular confinement. These amphiphilic HBPAAs also have potential for use as tracing nanocarriers and molecular-level containers. Self-condensation of this AB2 building block to construct water-soluble globular architectures with desired fluorescence properties appears to be a facile approach toward dendritic macromolecules with labeling-delivery applications. Recent publications 1. Lin L L, Chi M C, Lan E G, Lin M G, Juang T Y, et al. (2017) Facile immobilization of Bacillus licheniformis �?³-glutamyltranspeptidase onto graphene oxide nanosheets and its application to the biocatalytic synthesis of �?³-l-glutamyl peptides. International Journal of Biological Macromolecules pii: S0141-8130(17)32915-X. 2. Kan S C, Lee C C, Hsu Y C, Peng Y H, Chen C C, et al. (2017) Enhanced surfactin production via the addition of layered double hydroxides. Journal of the Taiwan Institute of Chemical Engineers 80:10. 3. Juang T Y, Hsu Y C, Jiang B H and Chen C P (2016) Highly efficient inverted organic photovoltaics containing aliphatic hyperbranched polymers as cathode modified layers. Macromolecules 49:7837. 4. Juang T Y, Kan S J, Chen Y Y, Tsai Y L, Lin M G, et al. (2014) Surface-functionalized hyperbranched poly(amido acid) magnetic nanocarriers for covalent immobilization of a bacterial �?³-glutamyltranspeptidase. Molecules 19:4997. 5. Su Y A, Chen W F, Juang T Y, Ting W H, Liu T Y, et al. (2014) Honeycomb-like polymeric films from dendritic polymers presenting reactive pendent moieties. Polymer 55:1481.

Biography

Tzong-Yuan Juang is an Assistant Professor in the Department of Cosmeceutics, China Medical University, Taiwan. His research interests are focused on developing water-soluble dendritic macromolecules including dendrimers and hyperbranched macromolecules, and studying their supramolecular chemistry in solution and the relationship and applications at organic/inorganic interfaces. Potential application areas such as molecular exfoliation for 2D layered graphene and natural clay, fluorescent carrier molecules for container and drug delivery for biomedical applications.
Email:tyjuang@mail.cmu.edu.tw