Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar
Effect Of Micellar Solubilization Technology On The Anticancer Activity Of Dasatinib: A Study On The In Vitro Survival Of Cell Lines | 4604
Journal of Biotechnology & Biomaterials
Like us on:
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
In the present research work micellar solubilization technology has been employed for the formulation development of poorly
soluble Dasatinib and its effect is evaluated basing upon the cytotoxic activity. Dasatinib is an oral multi- BCR/ABL and Src family tyrosine kinase inhibitor approved for use in patients with chronic myelogenous leukemia (CML) after imatinib treatment and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). The formulation development for Dasatinib was done by improving its solubility by micellar solubilization technology. The resulted micellar solution was converted into spray dried powder. The MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay was carried out on Baf3/WT, E255k and K562 for the evaluation of the cytotoxic activity of placebo, pure drug, and formulation. Suitable and
equivalent dilutions were made for the three samples to evaluate the effect on the inhibition of cell proliferation by MTT Assay.
The IC 50 value reveals that formulation of Dasatinib has shown a better inhibition effect on the cell proliferation than that of
pure drug which may be due to more uptake of drug into the cells. Moreover, inhibition of Pgp efflux and fluidization of the cellular structure by the surfactant also accounts for the lower IC 50 value of formulation on Baf3/WT and E255k. This concludes that micellar solubilization technology employed for the solubility enhancement of Dasatinib has also resulted better inhibitory activity of Dasatinib on cell proliferation.
P. Durga Maheswari is pursuing Ph.D. entitled ?Formulations of poorly water soluble drugs using micellar solubilization technology?, from Jawaharlal Nehru Technological University, Hyderabad, AP, INDIA. She had completed M. Pharm in Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam, A.P, INDIA. She is working as Senior Manager, Formulation Research & Development, Natco Research Center, Sanath Nagar Hyderabad.
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals