alexa Enhanced Anti-cancer Efficacy Of Bromelain Nanoparticles Against Ehrlich Ascites Carcinoma Upon Oral Administration
ISSN: 2476-2067

Toxicology: Open Access
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

8th World Congress on Toxicology and Pharmacology
April 13-15, 2017 Dubai, UAE

Priyanka Bhatnagar and Kailash Chand Gupta
All India Institute of Medical Sciences, India
Posters & Accepted Abstracts: Toxicol Open Access
DOI: 10.4172/2476-2067.C1.003
Abstract
Oral administration of anti-cancer drugs is an effective alternative to improve their efficacy and reduce undesired toxicity. Bromelain (BL) is known as an effective anti-cancer phyto-therapeutic agent; however, its activity is reduced upon oral administration. As a result, BL was encapsulated in Poly lactic-co-glycolic acid to formulate nanoparticles (NPs), which were further coated with Eudragit L30D polymer in order to provide stability against the gastric acidic conditions upon oral delivery of NPs. NPs were characterized for BL entrapment, proteolytic activity and mean particle size. The stability and release pattern of NPs was also evaluated under simulated gastrointestinal tract pH conditions. Cytotoxicity studies, carried out in human cell lines of diverse origin showed a significant dose advantage (~7-10 folds) with NPs in reducing the IC50 values as compared to free BL. The cellular uptake of NPs in MCF-7, HeLa cells and Caco-2 cell monolayer was significantly enhanced several folds as compared to free BL. Altered expression of marker proteins associated with apoptosis and cell death (P53, P21, Bcl2, Bax) also confirmed the enhanced anti-carcinogenic potential of formulated NPs. Oral administration of NPs reduced the tumor burden on mice and also increased their life-span when compared with the free BL. The generation of reactive oxygen species, induction of apoptosis and impaired mitochondrial membrane potential in tumor cells treated with NPs confirmed the suitability of NPs as a promising candidate for oral chemotherapy.
Biography

Email: [email protected]

image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords