Etiology Of Aplastic Anemia In India: A Study Based On Laboratory Investigation | 14131
Journal of Biotechnology & Biomaterials
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Disease Management and prognostication of aplastic
anemia (AA) depends on etiology i.e. constitutional vs.
acquired. Mitomycin-C induced stress cytogenetics
distinguishes between the two. Th ere is scant data on the
demographic distribution, etiology and prevalence of
constitutional aplasia in India. Peripheral blood samples
from 300 patients were processed for chromosomal
breakage study. Patients were examined for the presence
of phenotypic features of constitutional aplastic anemia.
Hemogram, bone-marrow biopsy results and data of
demographic distribution and infectious etiology were
documented. Th e incidence rate of AA was 1.97 cases
per million per year. Th e male to female sex ratio was
3.2:1. Strong association between survival rate and
severity was found with hazard ratio 0.39. Hepatitis
infection was also observed frequently among patients
(odds ratio, OR: 0.99; 95% confi dence interval, CI:
0.99-1.00). In this cohort, 9.40% had evidence of
constitutional aplastic anemia. In view, of the high
mortality rate and therapeutic implications, it should
be mandatory for all patients with aplastic anemia to
undergo this investigation prior to initiation of therapy.
Th e skewed sex ratio in our study probably refl ects the
gender bias in our society. Higher percentage of AA
cases was observed in northern states of India viz. Bihar,
Delhi/NCR & Uttar Pradesh.
I, Dharmendra Jain, is working as a Scientist at Molecular Genetics & Immunology laboratory of Medanta, The Medicity Hospital, Gurgaon Haryana, India and and a registered Ph.D candidate of Amity Institute of Biotechnology, Amity University, Uttarpradesh, India.
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