Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar


Evaluation Of Nitric Oxide And Ciprofloxacin Against Typhoid | 4871
ISSN: 2155-952X

Journal of Biotechnology & Biomaterials
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Google Scholar citation report
Citations : 2154

Journal of Biotechnology & Biomaterials received 2154 citations as per Google Scholar report

Indexed In
  • Index Copernicus
  • Google Scholar
  • Sherpa Romeo
  • Open J Gate
  • Genamics JournalSeek
  • Academic Keys
  • ResearchBible
  • China National Knowledge Infrastructure (CNKI)
  • Access to Global Online Research in Agriculture (AGORA)
  • Electronic Journals Library
  • RefSeek
  • Hamdard University
  • OCLC- WorldCat
  • SWB online catalog
  • Virtual Library of Biology (vifabio)
  • Publons
  • Geneva Foundation for Medical Education and Research
  • Euro Pub
Recommended Journals
Share This Page

Evaluation of nitric oxide and ciprofloxacin against typhoid

3rd World Congress on Biotechnology

S. S. Haque

ScientificTracks Abstracts: J Biotechnol Biomater

DOI: 10.4172/2155-952X.S1.009

Background: Typhoid caused by Salmonella typhi remains a major health concern worldwide. The emergence of multidrugresistant (MDR) strains of Salmonella with increased virulence leading to increased morbidity and mortality has further complicated its management. Human typhoid is similar to the infection caused by Salmonella typhimurium in mice. Most of the antibiotic are resistant and vaccines have less-than-desired efficacy and certain unacceptable side effects, making it pertinent to search for new suitable formulation. Nitric oxide (NO) is a gaseous free radical molecules; produced in biological systems. During enzymatic conversion of L-arginine to L citrulline by NO synthase (NOS) nitric oxide is produced. Ciprofloxacin one such fluoroquinolones have been shown to achieve high intracellular concentrations and least resistant antibiotic used against typhoid. Exogenous administration of L arginine results in increased NO production, indicating that endogenous substrate is insufficient for maximal NO production. By considering these facts, it was thought to see the effect of oral administration of NO donor i.e. L-arginine along with the low doses of antibiotic (ciprofloxacin). Material and methods: NO estimation was done by the fluorometric method Misko et al., (1993) with slight modification. Results and Discussion: Hepatic nitrite level in mice infected with 0.6xLD50 of S. typhimurium was 8.33%, higher than control animals (treated with saline) at day 8,and in group B+Arg, B+Cip & B+1/2Arg+1/2Cip were 16.66%, and 12.5% & 10.25% respectively as compared to only S. typhimurium infected mice. Formulation of L-arginine and ciprofloxacin shows better therapeutic induction against typhoid. Conclusion: This increase of nitrite level (metabolites of nitric oxide) is may be due to enhanced cytokine expression.
S.S. Haque Biochemist in Indira Gandhi Institute of Medical Sciences Patna-14 one of premier medical institute of India( and did his Ph.D (Biochemistry) from Hamdard University New Delhi -62 and awarded ?Bharat Joyoti? in 2012 and he is working on Typhoid and nitric oxide. He has published more than 15 papers in reputed journals and serving as an editorial board member of different journal Associate editor of Journal of Infectious Diseases Letters, ISSN: 0976-8904 & E-ISSN: 0976-8912, Editor of the Continental Journal of Biological Sciences, Web med central (Open Access Biomedical Publisher Using Post Publication Peer Review) Appointed Biochemistry Faculty and Editorial board member International Research Journal of Applied Life Sciences.