alexa Expression Of Beclin-1, Bcl-2, Bcl-xL, Bad, And Bax In HCV Patients In Relation To Grade Of Hepatic Fibrosis
ISSN: 2332-0877

Journal of Infectious Diseases & Therapy
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

6th Euro-Global Conference on Infectious Diseases
September 07-09, 2017 | Paris, France

Tarek K Motawi, Eman A Amer and Mustafa A Elshobaky
Cairo University, Egypt
Ahram Canadian University, Egypt
Posters & Accepted Abstracts: J Infect Dis Ther
DOI: 10.4172/2332-0877-C1-033
Abstract
Autophagy plays an important role in the pathogenesis of many diseases. However, its role is still unclear. We investigate the mRNA expression of Beclin-1 (major autophagic agent), pro-apoptotic agents (Bad, Bax), and anti-apoptotic agents (Bcl-2, Bcl-xL) in blood samples withdrawn from Genotype 4 HCV-infected patients with different stages of hepatic fibrosis. The study was a retrospective one that included 30 healthy people (Control Group), 64 chronic hepatitis C patients with early hepatic fibrosis stages [grade 0 and 1 fibrosis] (F0-1 Group), and 36 chronic hepatitis C patients with Late hepatic fibrosis stages [grade 2 and 3 fibrosis] (F2-3 Group). qPCR was used to measure mRNA expression in the samples. Beclin-1, Bad, and Bax mRNA expression in F0-1 Group were significantly higher than both F2-3 Group and Control Group (P<0.001). While Bcl-2, and Bcl-xL mRNA expression in F0-1 Group were significantly lower than both F2-3 Group and Control Group (P<0.001). Beclin-1, Bad, and Bax mRNA expression were increased at the early stages of hepatic fibrosis in HCV patients, and were declined as the fibrosis progressed to more advanced stages, while Bcl-2, and Bcl-xL mRNA expression were increased as fibrosis progresses. This shows that autophagy has an important role in the early stages of hepatic fibrosis in Genotype 4 HCV patients. These findings provide an insight into the pathogenesis of chronic HCV infection, and the effect of autophagy on liver fibrosis. This may be used to provide possible biomarkers and contribute to a new therapeutic approach.
Biography

Tarek K Motawi is a Professor of Biochemistry, Faculty of Pharmacy, Cairo University. Egypt. He obtained PhD in Pharmaceutical Sciences in 1984, MSc in Pharmaceutical Sciences in 1979 and BSc in Pharmaceutical Sciences from Faculty of Pharmacy, Cairo University in 1976. He worked as an Instructor in 1976 and became Assistant Lecturer in 1980, Lecturer in 1984 and Assistant Professor in 1989. He was promoted to the position of Professor in 1994 and worked as Head of the Department of Biochemistry, Faculty of Pharmacy, Cairo from 2008 to 2014.

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords