Functional Variants Data Implication Of Single Nucleotide Polymorphism Of MyBPH Gene Associated With The Skeleton Muscle Growth In Jeju Native Pig And Berkshire As A Novel Candidate Gene For Trail Selection | 34009
Journal of Biotechnology & Biomaterials
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Functional variants data implication of single nucleotide polymorphism of MyBPH gene associated with the skeleton muscle growth in Jeju native pig and Berkshire as a novel candidate gene for trail selection
Sus scrofa is considered an important animal for meat production. During the last decade pork quality is one of the main
selection criteria for breeding in the swine industry and thus attracted much more research focus. Jeju Native Pig (JNP) is a
typical pig breed in South Korea highly appreciated by Korean consumers; however the slower growth rate and lighter carcass
weight than commercial pig breeds led the farmers move away from traditional pig farming to typically intensively muscular
traits farming. One recent approach relies to identify the key gene and its SNPs as molecular markers and have been tried for
their use in traceability systems in livestock. The present study focused on the association of polymorphisms in the Myosin
binding protein H (MyBPH) with skeletal muscle development in the JNP and Berkshire pigs. Validation of expression of
genes in the laboratory also supported the idea of differential expression of MyBPH conceived through the in silico analysis.
Gene ontology analysis of MyBPH showed significant association with muscle contraction and muscle organ development. The
concordant in silico analysis of MyBPH by using the various tools identified potential four nsSNPs (W93T, D218R, D230W
and W315V) in JNP. Our nsSNPs analysis retrieved high deleterious effects at second coding region in JNP compared with
Berkshire. This study is an in-depth pioneering in silico analysis of polymorphic MyBPH and will be a valuable resource for
further targeted molecular diagnosis and population-based studies for improving the growth performance of the JNP.
Dong Kee Jeong is a Professor of the Department of Animal Science at Jeju National University and Director of Internship support center, Chair person for the subcommittee of horse. He also occupied various honorable positions in his carrier. During 2009-2010, he was a Visiting Professor at the Department of Biomedical Sciences and Department of Veterinary Sciences, University of Calgary. He has received his PhD in Animal Molecular Genetics from the Seoul National University in 1999. He worked as Post-doctoral Fellow at Washington State University and The Johns Hopkins University. His research interests center on Cancer Stem Cell and System Biology. He has published more than 70 papers in reputed journals and has been serving as an Editorial Board Member of Asian-Australasian Journal of Animal Sciences.