Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers
Google Scholar citation report
Citations : 2154
Journal of Biotechnology & Biomaterials received 2154 citations as per Google Scholar report
Indexed In
- Index Copernicus
- Google Scholar
- Sherpa Romeo
- Open J Gate
- Genamics JournalSeek
- Academic Keys
- ResearchBible
- China National Knowledge Infrastructure (CNKI)
- Access to Global Online Research in Agriculture (AGORA)
- Electronic Journals Library
- RefSeek
- Hamdard University
- EBSCO A-Z
- OCLC- WorldCat
- SWB online catalog
- Virtual Library of Biology (vifabio)
- Publons
- Geneva Foundation for Medical Education and Research
- Euro Pub
- ICMJE
Useful Links
Recommended Journals
Related Subjects
Share This Page
In Association with
Functionalized copolymer matrix based on poly(maleic anhydride-co-3, 9-divinyl-2, 4, 8, 10-tetraoxaspiro (5.5) undecane) with potential biomedical applications
Annual Conference and Expo on Biomaterials
Iordana Neamtu, Aurica P Chiriac, Loredana E Nita, Vera Balan, Alina Diaconu and Liliana Tartau
Petru Poni Institute of Macromolecular Chemistry, Romania
Posters & Accepted Abstracts: J Biotechnol Biomater
Abstract
Utilization of polymers as biomaterials is greatly impacted the progress of modern medicine. In order to fit functional demand, materials with desired physical, chemical, biological, biomechanical and degradation properties must be selected. Luckily, a wide range of natural and synthetic degradable polymers are investigated for biomedical applications with novel materials constantly being developed to meet new challenges. The present study is focused on the poly(anhydride maleic-co-3,9-divinyl-2,4,8,10-tetraoxaspiro[5.5]undecane) new copolymer synthesis by radical polymerization in dioxane, using 2,2´-azobis(2-methylpropionitrile) as free-radical initiator. The polymer matrix is subsequently modified with mesoerythritol to open maleic anhydride ring with the aim to afford supplementary functions necessary for polymer matrix coupling with bioactive substances. Antioxidant characteristics are conferred too. Both comonomers are able for generating special effects as for example network formation, biodegradability and biocompatibility, gel formation capacity, binding properties, amphiphilicity, good oxidative and thermal stability, good film formers and temperature and pH sensitivity. The resulted structure is evidenced by common spectroscopic analyses, while the dual pH and temperature sensitivity is evaluated by determining the hydrodynamic radius and zeta potential. The antioxidant character is evaluated measuring the scavenger properties of the functionalized copolymer with erythritol against the 2,2-diphenyl-1-picrylhydrazyl radicals. The acute toxicity of the synthesized macromolecular compounds is estimated in vivo by mice oral administration followed by medial lethal dose determination (LD50). The obtained data include the compounds into the group of moderately toxic accordingly to Hodge and Sterner toxicity scale.Biography
Iordana Neamtu has published more than 50 papers in quotated journals and participated in more than 15 Romanian projects.
Email: danaiordana@yahoo.com
