HLA-DR And DQ Antigens In Iranian Patients With Oral Lichen Planus, A Descriptive Crosssectional Study | 14129
Journal of Biotechnology & Biomaterials
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Oral lichen planus (OLP) is a chronic infl ammatory
mucocutaneous disease. Th e cause of lichen planus is
not known. Oral lichen planus aff ects women more than
men (1.4:1). Oral lichen planus occurs predominantly
in adults over 40, although younger adults and children
may be aff ected.
Th e purpose of this study is to determine relationship
between HLA-DR and DQ antigen and oral lichen
Whole blood sample of Oral lichen planus patient
were subjected to study the HLA-DR and DQ, with
Oral lichen planus patients were selected for HLADR
and DQ typing with PCR method.56 patients (42
woman and 14 men) tested. A strong association was
found between HLA-DR3 and OLP. But there was not
relationship betweenHLA-DQand OLP disease.
Fift y six OLP patients (42 woman and 14 men)
were subjected to conventional PCR-SOP for HLA-DR
and DQ typing (Innotrain, Germany). Predominant
HLA- DR were HLA -DR3 (61.2%). But there was not
relationship between HLA DQ and OLPdisease.
HLA-DR3 is signifi cantly higher in oral lichen
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