alexa How Secreted AGR2 Helps Tumor Cells To Establish Its Microenvironment
ISSN: 2155-952X

Journal of Biotechnology & Biomaterials
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

5th World Congress on Biotechnology
June 25-27, 2014 Valencia Conference Centre, Valencia, Spain

Dawei Li
Keynote: J Biotechnol Biomater
DOI: 10.4172/2155-952X.S1.026
Abstract
The establishment of tumor microenvironment involves cell-cell signaling between tumor and normal cells. These signaling molecules are responsible for tumor vascularization, cell migration and integration of normal and tumor cells to form tumor microenvironment that supports tumor formation, growth and metastasis. Several major molecules including VEGF, FGF and EGF and their receptors have been successfully targeted by monoclonal antibodies for cancer treatment, proving their importance in anti-cancer drug development. How these signaling pathways are coordinated and regulated are important for the better understanding of cancer microenvironment and for the development of new strategies against cancer. AGR2 is both a cellular and secreted molecule that has been reported as a tumor marker and a promoter of cancer formation. We have reported that secreted AGR2 promotes blood vessel formation and the blocking of AGR2 by a monoclonal antibody will reduce tumor formation, indicating AGR2 is an extra cellular signaling molecule that plays a pivotal role in tumor microenvironment establishment. Here we report the mechanisms of how secreted AGR2 participates in the microenvironment building process that is already dominated by major players like VEGF, EGF and FGF and their receptors. We will describe our new findings that link AGR2 with tumorigenesis and tumor vascularization and surrounding normal cells especially endothelial cells responsible for new blood vessel formation and supplying nutrients for tumor cells. Our data strongly suggest that AGR2 is a multifunctional local guidance molecule participating cancer microenvironment network buildup by altering the signals of other key players in angiogenesis and cell migration.
Biography
Dawei Li completed his PhD from Ohio State University and postdoctoral studies from Harvard University School of Medicine in the US. He is currently a principle investigator in medicinal biotechnology at School of Pharmacy and Center for Cell Engineering and Antibody Medicine at Shanghai Jiao Tong University. He has published more than 25 papers in reputed journals and 4 approved patents. He is a board member of the Committee for Biochemical Pharmaceutics, Shanghai Pharmaceutical Association and a member of Steering Committee for Student Educational Affairs Management at Shanghai Jiao Tong University.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version