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Hydrocolloids: New Suspending Agents For Oral Formulations | 4868
Journal of Biotechnology & Biomaterials
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Pharmaceutical suspensions are thermodynamically unstable systems consisting of two phases thus a stabilizer/suspending
agent is an integral part of its dosage form. The Suspending agents used for pharmaceutical suspensions are mostly utilized from
guar extracted from Cyamopsis tetragonoloba and tora gum extracted from Cassia tora. Their history for use as a pharmaceutical
suspension holds long and has been utilized in the past. The present research deals provide an insight into pharmaceutical liquid
suspension formulations using novel natural hydrocolloids from Cassia grandis, Cassia alata and its carboxymethyl derivative as
suspending agents suitable for oral administration which remain stable and the value added novel galactomannans have a longer
shelf life. There were more than 150 Set of Formulations prepared with both gums and their carboxymethylated derivatives
ranging from 0.01-0.15 %, the drug taken i.e., Phyllanthus nirrui was in all cases 1 % besides adding 0.01 % of sodium benzoate
as preservative and PEG as surfactant. In other sets prepared, 0.1M and 0.5M of KCl, BaCl2 and FeCl3 were taken to know the best
electrolyte and in still other sets prepared pH 3, 7 and 9 were used to assess the optimum pH. Formulation remained stable for
> 2 years. Among all the QQP?s, Redispersibility number was found to be very less which indicates better suspension. This paper
thus introduces a novel and alternative source of hydrocolloid for its use as a suspending agent.
Harsha Kharkwal is Assistant Professor and Coordinator at Amity Center for Carbohydrate Research. She completed her Ph.D from National
Botanical Research Institute, CSIR and continued her research work at University Institute of Chemical Technology, Mumbai. She is the recipient of
Lucid research Award for 2004, has published more than 25 papers in Journals of repute, she has edited 1 book and has filed more than 40 patents.
In such a short span, she has even guided 2 Ph.D students.
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