Immobilized Metal-organic Frameworks Films For Bio-sensing Applications | 39112
Journal of Biotechnology & Biomaterials
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Metal Organic Frameworks (MOF) and their derived compounds have become an important area of research in materials
chemistry. Due to enormous advantages of MOFs, researchers are exploiting them for a number of technological
applications such as in sensing, gas storage, separations, catalysis, luminescence, etc. The coordination geometry of the metal
and the topology of the linkers in the MOFs provide strong chemical bonds and ordered structure to these compounds, thus
imparting high thermal and chemical stability. Post synthetic modification further imparts additional properties that can be
exploited in applications such as bio-sensing, imaging, drug delivery etc. In the present work, Cu-MOF films have been grown on
alumina substrate as a robust bio-sensing platform using solvothermal technique at room temperature. The topological studies
of as-grown films were carried out using field emission scanning electron microscope (FE-SEM) and Atomic Force Microscopy
(AFM). The synthesized MOF was characterized using UV-Vis spectroscopy, FTIR, XRD and FE-SEM. The conductivity to the
synthesized MOF films was introduced by immersing in TCNQ/chloroform solution for 72 hours. Anti-BSA antibodies have
been conjugated to the pendent groups of MOF film using EDC-NHS chemistry. The developed biosensor can be explored
further for the conductometric sensing of counter antigen i.e., BSA protein by measuring change in conductivity of MOF film
for development of specific and sensitive sensors for bio-sensing applications.
Atal Anudeep Singh Gill is currently a student at Amity University (Noida). He is pursuing his BTech+MTech (dual) Nanotechnology degree. His research interests are MEMs, NEMs, Bio-electronic nanosensors, solar cells and fuel cells.