Impairment Of Diabetic Wound Healing: Key Genetic Players | 38996
ISSN: 2155-952X

Journal of Biotechnology & Biomaterials
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Recommended Conferences

2nd International Conference on Biotechnology and Healthcare

Auckland, New Zealand
Google scholar citation report
Citations : 1514

Journal of Biotechnology & Biomaterials received 1514 citations as per google scholar report

Indexed In
  • Index Copernicus
  • Google Scholar
  • Sherpa Romeo
  • Open J Gate
  • Genamics JournalSeek
  • Academic Keys
  • ResearchBible
  • China National Knowledge Infrastructure (CNKI)
  • Access to Global Online Research in Agriculture (AGORA)
  • Electronic Journals Library
  • RefSeek
  • Hamdard University
  • OCLC- WorldCat
  • SWB online catalog
  • Virtual Library of Biology (vifabio)
  • Publons
  • Geneva Foundation for Medical Education and Research
  • Euro Pub
Share This Page

Impairment of diabetic wound healing: Key genetic players

6th World Congress on Biotechnology

Kiran Singh and Kanhaiya Singh

Banaras Hindu University, India

ScientificTracks Abstracts: J Biotechnol Biomater

DOI: 10.4172/2155-952X.C1.043

Type-2 Diabetes Mellitus (T2DM) is a multifactorial disease characterized by hyperglycaemia and a series of micro- and macro-vascular secondary complications including wound healing impairment. Acute inflammation is necessary for wound healing as it brings about proper wound debridement. During the inflammatory phase of wound healing, innate immune system activation is crucial to combat invading microbes. Toll like receptors (TLRs) are the important members of innate immune system and are shown to be an important regulator of wound repair and regeneration in mouse model. We observed differential expression of extracellular TLRs in human diabetic wounds. Epigenetic silencing mediated by methylation analysis of CpGs of promoter regions of TLR2 and TLR4 revealed that this mechanism is contributing towards the downregulation of TLR2 and TLR4. Some endosomal TLRs like TLR7 and TLR9 have been shown to promote tissue necrosis and sensory neuropathy. The levels of these endosomal TLRs were found to be significantly elevated in diabetic wounds along with their signalling molecules like S100A8 and IL8.Recruitment of anti-inflammatory CD11b+CD33+ myeloid cells during initial phase of wound healing is necessary for proper healing. Comparative analysis of the counts of these CD11b+ CD33+ myeloid cells using flow cytometry in healthy controls, T2DM cases and Diabetic foot ulcer (DFU) cases revealed the reduced level of these cells to be involved in the impairment of wound healing. In conclusion, our study indicated that the combined genetic and epigenetic deregulation of immuno-inflammatory phase due to persistent hyperglycaemia lead to development of chronic ulcers in T2DM subjects.

Kiran Singh has completed her PhD from Cytogenetics Laboratory, Department of Zoology; Banaras Hindu University in 2005. She is currently working as an Assistant Professor in Department of Molecular and Human Genetics, Banaras Hindu University. Her area of interest includes molecular human reproductive genetics, clinical cytogenetics & genetics and epigenetics of diabetic wound healing impairment. She has published 48 papers in various national and international journals and has been serving as Reviewer and Editorial Board Member of various reputed journals.

Email: [email protected]