Implementation Principle And Animal Study Of Analgesia Using Great Needling | 104613
Journal of Traditional Medicine & Clinical Naturopathy
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Great Needling has been a way of acupuncture analgesia recorded in Huang Di Nei Jing. The principle ???Pain up, needle down; and
pain left, needle right??? meaning the acupoint selection is far from the painful area, which is the main difference compared to
general acupuncture. Therefore, this takes advantage in treating acute pain or around the lesion where acupuncture is not indicated.
However, there is no specific description about the implementation in Huang Di Nei Jing and not in other later ancient literatures
and the current studies of acupuncture analgesia using remote acupoint selection show inconsistent and even contradictory results.
There are accumulating evidences surrounding the therapeutic effect of Electroacupuncture (EA). Transient Receptor Potential
Vanilloid1 (TRPV1) and associated signaling pathways have been reported to be increased in inflammatory pain signaling. Local
EA can reliably attenuate inflammatory pain and the increase of TRPV1 in mouse with unclear mechanisms. However, the effect
of EA on distal and contralateral acupoint for pain control has been rarely studied and the result was controversial. Also, we
developed Great Needling based on the theories of Same Name Meridians and Holographic Biology which are commonly adopted
principles in clinical acupuncture treatment. We try to apply these methods in Great Needling with electroacupuncture to create
a clear positioning theory of remote acupuncture analgesia and design further animal study assessing efficacy of analgesia with
TRPV1. Here in our study, we found that inflammatory hindpaw pain in mouth, which was induced by injecting the Complete
Freund???s Adjuvant (CFA), (2.65±0.34, p<0.05, n=6) for 2 days can be alleviated immediately after EA treatment (2 Hz, 15 minutes,
1 ma), (4.41±0.47, p<0.05, n=6) at contralateral forefoot acupoint LI4 through both mechanic and thermal behavior tests, while
sham acupoint group is not. The efficacy was observed to be more obvious after the second round of EA treatment on the following
day. The expression of TRPV1 and associated signaling pathways notably increased after the CFA injection; this expression can be
further attenuated significantly in EA treatment. This analgesic effect is believed to be produced by applying EA to a site remote
from the painful area based on Great Needling. The present study provides a powerful experimental animal model that can be used
for investigating the unique physiological mechanisms involved in acupuncture analgesia
Tong-Chien Wu has received his MD cum laude from China Medical University and has been devoted to clinical practice in Traditional Chinese Medicine in Taiwan. He has completed Specialist degrees of Acupuncture Medicine and Traditional Chinese Internal Medicine. He is currently serving as an Attending Physician in Integrated Chinese and Western Medicine of Chung Shan Medical University Hospital. He has also completed his Master’s degree at Research Institute of Acupuncture Science in China Medical University. His expertise includes metabolic diseases and pain control.