alexa In Vitro Characterisation Method For Comparative Evaluation Of Drug Loaded Embolic Distal Perfusion | 41665
ISSN: 2155-952X

Journal of Biotechnology & Biomaterials
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Recommended Conferences
Share This Page

In vitro characterisation method for comparative evaluation of drug loaded embolic distal perfusion

Annual Conference and Expo on Biomaterials

Caine M, Capretto L, Carugo D, Zhang X, Hill M, Willis SL, Dreher MR and Lewis AL

Biocompatibles UK Ltd, UK

Posters & Accepted Abstracts: J Biotechnol Biomater

DOI: 10.4172/2155-952X.C1.050

In vitro biomimetic models have become increasingly utilised in the evaluation of medical devices over the last 30 years. Application in the field of Interventional Oncology for modelling purposes has been limited by the complexity of recreating biological vascular systems. Interventional Oncology and specifically embolisation, varies significantly in terms of its administration methodology. The specific process of blocking the primary blood supply to a hyper-vascularised tumour is anything but simple in terms of reproducibility and translation between patients, clinics and devices. Flow properties of drugloaded embolic microspheres have been shown to influence the distribution, contact diffusion and spatial drug elution kinetics within tumours. Moreover, variations in the administration style of the physician have been shown to play a significant part in the intra-tumoural distribution. To model the unique flow properties of various embolic products, novel in vitro microfluidic test systems have been developed. Through compartmentalised recreations of clinical conditions, it becomes possible to predict and evaluate relevant flow properties prior to use in vivo. This presentation will analyse the effect of channel flow rate (Reynold’s number) and embolic size of doxorubicin loaded DC Bead™ 70-150μm and 100-300μm within in vitro flow channels of sizes representative of distal hepatic microvasculature. The effect of whole bead distribution is considered as a vehicle for distal drug distribution utilising clinically representative injection volumes for modelling bolus effects. A significantly higher dose (p=0.017) is observed in smaller flow channels with 70-150μm vs 100-300μm trending with increased flow rates.

Marcus is an Innovation Scientist at BTG. Initially focusing on analytical method development and validation, he is currently completing a part-time PhD with the University of Southampton in Applied Biomimetic Microfluidics and focusing on the application of this project to advancing treatment in the field of interventional oncology and pulmonology.

Email: [email protected]