alexa Incidence Of High-risk Human Papillomavirus Infection In Immuno Compromised Hosts
ISSN: 2332-0877

Journal of Infectious Diseases & Therapy
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

4th International Congress on Infectious Diseases
May 11-12, 2017 Barcelona, Spain

Maksims Cistjakovs, Alina Sultanova, Baiba Lesina-Korne, Rafail Rozental and Ieva Ziedina
August Kirchenstein Institute of Microbiology and Virology, Latvia
Pauls Stradins Clinical University Hospital, Latvia
Riga Stradins University, Latvia
Posters & Accepted Abstracts: J Infect Dis Ther
DOI: 10.4172/2332-0877-C1-024
Statement of the Problem: Cervical cancer is the second most common women cancer in the world. High-risk human papillomavirus (HR-HPV) infection is the most common cause and just two HPV types, 16 and 18, are responsible for about 70% of all cervical cancer cases. Due to long-term immunosuppressive therapy, renal transplant recipients have faster progression from infection to lesions and higher risk of developing cervical cancer. The purpose of this study is to compare frequency and viral load of HR-HPV in female renal recipients with immunosuppression, and in individuals without immunosuppression. Methodology & Theoretical Orientation: In this research, 16 patients were enrolled six months after renal transplantation and 16 inviduals without immunosuppression as a control group. Genomic DNA was extracted from cervical swabs. Polymerase chain reaction (PCR) with consensus primers was used for initial detection of high range HPV types. HR-HPV qPCR was used for quantitative detection of 12 types of HR-HPV (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, and 59). To detect HR-HPV16 and 18 types specific PCR was used. Findings: HPV DNA was detected in 12 out of 16 recipients (75%) and five of them (31%) were positive on HR-HPV infection. In contrast, seven out of 16 (43%) controls were positive HPV DNA and only one was positive on HR-HPV infection. Three recipients showed the highest viral load of HR-HPV (3,630,780, 4,655,860 and 29,512,092 copies/105 cells, respectively). From five patients with HR-HPV infection-one was positive on HPV16 and another one on HPV18. Only one individual from control group was positive on HR-HPV with 169,824 copies/105 cells. Conclusions: At point, the study is showing higher presence of HR-HPV infection with higher viral load in female recipients than in individuals without immunosuppression which means that they have higher risk of cervical dysplasia development.

Maksims Cistjakovs has over 10 years of working experience in Clinical Virology research. Main focus of his study is on “Immunomodulating properties of human herpesvirus-6 and high-risk papillomaviruses infection in immuno compromised hosts.

Email: [email protected]

image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version