Influence Of Microenvironment Engineering On Cell Reprogramming | 48965
ISSN: 2155-952X

Journal of Biotechnology & Biomaterials
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Influence of microenvironment engineering on cell reprogramming

10th Asia-Pacific Biotech Congress

Bogyu Choi

CHA University, South Korea

Posters & Accepted Abstracts: J Biotechnol Biomater

DOI: 10.4172/2155-952X.C1.056

The physical microenvironment has been reported to direct cell fate. Here, we found that the physical microenvironment, stiffness of hydrogels promotes the reprogramming of mouse embryonic fibroblasts into induced pluripotent stem cells (iPSCs). We prepared cell culture substrates of various stiffnesses (0.1, 1, 4, 10, and 20 kPa) using a polyacrylamide hydrogel. We found that culture on a soft hydrogel plays an important role in inducing cellular reprogramming into iPSCs via activation of mesenchymal-to-epithelial transition and enhancement of stemness marker expression. These results suggest that physical signals at the interface between cell and substrate can be used as a potent regulator to promote cell fate changes associated with reprogramming into iPSCs, which may lead to effective and reproducible iPSC production.

Bogyu Choi has completed her PhD from Ewha Womans University in 2010 from the Department of Chemistry and Nano Science and Postdoctoral studies from University of California, Los Angeles (2014), School of Dentistry. She is a Research Professor at CHA University. She has published more than 30 scientific papers and her papers were cited 630 times (h-index=16).

Email: [email protected]