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Inhibition against growth of glioblastoma multiforme in vitro using etoposide-loaded solid lipid nanoparticles with p-aminophenyl-�?±-D-manno-pyranoside and folic acid
8th Euro Biotechnology Congress
Chia-Hao Lee
National Chung Cheng University, Taiwan
Posters-Accepted Abstracts: Biotechnol Biomater
Abstract
Solid Lipid Nanoparticles (SLNs) grafted with p-Aminophenyl-�?±-D-Manno-Pyranoside (APMP) and Folic Acid (FA) (APMPâ�?�?FAâ�?�?SLNs) were applied to encapsulate 4â�?�?-demethylepipodophyllotoxin 9-(4,6-O-ethylidene-�?²-D-glucopyranoside) (etoposide) (ETP) for promoting the anti-proliferation of malignant glioblastoma multiforme. ETP-loaded APMPâ�?�?FAâ�?�?SLNs (APMPâ�?�?FAâ�?�?ETPâ�?�?SLNs) were used to penetrate the Bloodâ�?�?Brain Barrier (BBB) and retard the propagation of U87MG cells. An incorporation of APMP and FA increased the particle size, the cytotoxicity to U87MG cells and the permeability coefficient for propidium iodide and ETP across the BBB. In addition, an increase in the APMP and FA concentration reduced the zeta potential, the grafting efficiency of APMP and FA, the dissolution rate of ETP and the trans-endothelial electrical resistance. Immunochemical staining images evidenced that APMPâ�?�?FAâ�?�?ETPâ�?�?SLNs could infiltrate the BBB via glucose transporter 1 and recognize U87MG cells via folate receptor. APMPâ�?�?FAâ�?�?ETPâ�?�?SLNs can be an effective pharmaco-therapeutic formulation in targeting delivery to the brain and in inhibitory efficacy against tumorous cells for cancer therapy.Biography
Chia-Hao Lee is now studying his PhD in Department of Chemical Engineering National Chung Cheng University since 2014. His subject is nanotechnology for drugs delivery and designing the carrier of drugs such as solid lipid nanoparticles.
Email: alnwick704@gmail.com
