Interesting Results: Can They Be Replicated? | 33081
OMICS Journal of Radiology
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Negative results in replication attempts are, we believe, of particular value in imaging because they provide an empirical
basis by which to evaluate the reliability of findings. As part of the scientific enterprise, we know that replication, the
performance of another study statistically confirming the same hypothesis, is the cornerstone of science and replication of
findings is very important before any causal inference can be drawn. At the same time the publication bias is very common in
journals, favoring positive results. Furthermore, frequent publication is one of the few methods at medical scientists’ disposal
to demonstrate academic talent and to bring attention to their sponsoring institutions, which can facilitate continued funding
and an individual’s progress through academia. This workshop addresses the need for replication in imaging for two reasons.
Firstly, it skews the scientific literature by only including chosen pieces of information. Secondly, it causes a huge waste of time
and resources, as other scientists considering the same questions may perform the same imaging studies. Furthermore, given
that positive results are more easily published than negative data, it is extremely difficult to correct the scientific record for false
positives; controversial studies that conflict with or cannot reproduce previously published studies are seldom given space in
peer-reviewed journals. Thus all studies that are hypothesis-driven and describe results based on sound experimental planning
and execution should be shared with the scientific community, to avoid repetitive work, waste of resources and to correctly
inform future study designs.
Michael Winterdahl is an Associate Professor at Aarhus University and has been working in the field of medical imaging for the last eight years. Recently, he developed a new radioligand for brain imaging of neuropeptide Y type 2 receptors in the intact, living brain using positron emission tomography (PET). He has advanced the compound from initial tests using autoradiography, to preclinical small and large animal imaging, though kinetic modelling, and is now working to launch the first human administration.