alexa
Reach Us +1-947-333-4405
Lessons Learnt In A 17 Year Old With Fever Of Unknown Origin – Haemophagocytic Lymphohistiocytosisthe Most Fatal Outcome Of Ebstein-barr Virus Infection | 31399
ISSN: 2332-0877

Journal of Infectious Diseases & Therapy
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Lessons learnt in a 17 year old with fever of unknown origin – Haemophagocytic lymphohistiocytosisthe most fatal outcome of Ebstein-barr virus infection

World Congress on Infectious Diseases

Hajir Ibraheim, Kawai Yip and Siamak Arami

ScientificTracks Abstracts: J Infect Dis Ther

DOI: 10.4172/2332-0877.S1.002

Abstract

We report a young patient who had persistent fevers as a result of the most fatal outcome of an Ebstein-Barr Virus infection
-haemophagocytic lymphohistiocytosis (EBV-HLH).
A 17 year old girl with a background of IgG subclass deficiency presented to the accident and emergency department with
a history of fevers, sore throat and vomiting. Her blood tests showed an abnormal liver function and cytopenia. The clinical
impression was of EBV related infectious mononucleosis and this was supported by a positive monospot test and high EBV
DNA titres. Despite a decreasing level of EBV titres, she remained febrile and tachycardic with worsening liver function and no
improvement on broad spectrum antibiotics and anti-virals.
Repeated septic screens were negative and other viral infections were excluded. By day 16, HLH was considered by
the haematologists. A bone marrow biopsy then showed haemphagocytosis and repeat abdominal imaging showed new
hepatosplenomegaly. She was started on steroids with a rapid clinical and biochemical response.
This case highlights the importance of having a low threshold of suspicion for EBV-HLH in patients with EBV that continue
to deteriorate. The high mortality rate in this rare condition is partly due to delayed diagnosis as EBV-HLH can mimic other
infectious or inflammatory disorders.

Biography

Hajir Ibraheim is an ambitious 4th year junior medical doctor working in London. She has two publications in press and has presnetd multiple posters and
presentations on a national and international level. She is planning to undertake a masters in clinical research next year before pursuing a speciality post in
gastroenterology.

Relevant Topics
Top