alexa LilrB2 Inhibition Unlocks A New Hope In Alzheimer’s Disease Therapy
ISSN: 2155-952X

Journal of Biotechnology & Biomaterials
Open Access

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6th World Congress on Biotechnology
October 05-07, 2015 New Delhi, India

Ruchi Jakhmola Mani and Deepshikha Pande Katare
Amity University, India
Posters-Accepted Abstracts: J Biotechnol Biomater
DOI: 10.4172/2155-952X.C1.044
Abstract
Alzheimer’s disease (AD) is a progressive and irreversible brain illness which gradually abolishes one’s cognitive skills and rational thinking. The two major hallmarks of AD are the extracellular deposition of the Amyloid-beta (Aβ) fragments resulting in plaques and intracellular accumulation of neurofibrillary tangles of tau protein. LilrB2 is a recently discovered receptor for Aβ and is responsible for the increased accumulation and reduced clearance of Aβ from the brain. Therefore, LilrB2 inhibition can suppress the aggregation of Aβ plaques. In this study we have computationally modeled the 3D-structure of four isoforms of LilrB2. Structures were later super-imposed to calculate their RMSD and individually docked with Aβ to examine the most appropriate isoform for inhibition. Virtual screening of best isoform reports some potential compounds which can inhibit LilrB2. Studies are underway to validate the identified compounds in the animal model of AD.
Biography

Ruchi Jakhmola Mani is a PhD scholar and Faculty of Bioinformatics at Amity Institute of Biotechnology, Amity University, India. She has completed her Master’s degree in Bioinformatics from Panjab University, Chandigarh. She has six years of teaching experience with some peer-reviewed publications. At present, she is working with zebrafish model of Alzheimer’s disease.

Email: [email protected]

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