Journal of Biotechnology & Biomaterials
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The liver is a metabolically versatile organ responsible for the regulation of man?s internal chemical environment. The main function of liver is to synthesize an array of body proteins and to act as the detoxifying centre for the multiple toxic metabolic byproducts endogenous to the body and the toxins ingested daily by the organism. The liver?s main function is to synthesize an array of body proteins and to act as the detoxifying centre for the multiple toxic metabolic byproducts endogenous to the
body and the toxins ingested daily by the organism. Unique metabolism and relationship of the liver to the gastrointestinal tract make it an important target of the toxicity of the drugs and xenobiotics. Therefore examination of blood and liver become significant to help in the diagnosis and treatment of the diseases. The liver undergoes dramatic changes in structure and function during development. The developmental changes that occur in the liver determine the rate and metabolic pathways used in
the disposition of drugs and other xenobiotic. In toxicology liver plays an important role because all substances absorbed by the gastrointestinal tract pass through it before entering into the general circulation .Blood is highly specialized liquid connective tissue. Some toxicants cause direct injury to liver and others convert the chemicals into toxic substance through metabolic conversion. The classification may focus on the source and the chemical class of the toxicant, on the circumstances of exposure on the type of hepatic lesion produced, on the cell structure damaged or on the molecular or cellular mechanisms
involved. Idiosyncratic reaction is attributable to pharmacogenetic differences between individuals (genetic polymorphism in the
metabolism of compounds). In the case of severe toxicity the patient may develop liver failure. Cytotoxic injury resembles acute
hepatitic and is characterized by damage to the hepatocytes with prominent elevation of amino transferse. Severe case may result
in fulminant liver failure. Due to the presence of different types of cells blood has varied functions and analysis of its components
helps in evaluating the abnormal conditions which create pathological conditions in a person. Therefore examination of blood
and liver become significant to help in the diagnosis and treatment of the many diseases including cancer.
Rajesh K. Bhaskar worked as Guest Faculty in the Department of Molecular Biology, Kannur University ,Kerala .,India and doing his Ph.D. in the
School of Biosciences ,Mahatma Gandhi University, Kottayam, Kerala. India. He has paper publications in reputed journals like Indian Journal of
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